TY - JOUR
T1 - Sexual behaviours and the risk of head and neck cancers
T2 - A pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium
AU - Heck, Julia E.
AU - Berthiller, Julien
AU - Vaccarella, Salvatore
AU - Winn, Deborah M.
AU - Smith, Elaine M.
AU - Shan'gina, Oxana
AU - Schwartz, Stephen M.
AU - Purdue, Mark P.
AU - Pilarska, Agnieszka
AU - Eluf-Neto, Jose E.
AU - Menezes, Ana
AU - McClean, Michael D.
AU - Matos, Elena
AU - Koifman, Sergio
AU - Kelsey, Karl T.
AU - Herrero, Rolando
AU - Hayes, Richard B.
AU - Franceschi, Silvia
AU - Wünsch-Filho, Victor W.
AU - Fernández, Leticia
AU - Daudt, Alexander W.
AU - Curado, Maria Paula
AU - Chen, Chu
AU - Castellsague, Xavier
AU - Ferro, Gilles
AU - Brennan, Paul
AU - Boffetta, Paolo
AU - Hashibe, Mia
N1 - Funding Information:
Grant from the US National Institutes of Health; National Cancer Institute (NCI) (R03CA113157). The individual studies were funded by the following grants: Central Europe study: World Cancer Research Fund and the European Commission’s INCOCOPERNICUS Program (Contract No. IC15-CT98-0332); Seattle study [NIH (R01CA048896, R01DE012609)]; Iowa study—NIH National Institute of Dental and Craniofacial Health (NIDCR) (R01DE11979), NIDCR (R01DE13110), NIH Fogarty International Collaborative Research Award (TW01500) and Veterans Affairs Merit Review Funds—Latin America study: Fondo para la Investigacion Cientifica y Tecnologica (Argentina), Institut Municipal d’Invesigacio Medica (Barcelona), Funda¸cão de Amparo à Pesquisa no Estado de São Paulo (No 01/01768-2), European Commission (IC18-CT97-0222); IARC Multicentre Study [Fondo de Investigaciones Sanitarias of the Spanish Government (FIS 97/0024, FIS 97/0662 and BAE 01/ 5013), International Union Against Cancer, and Yamagiwa-Yoshida Memorial International Cancer Study Grant]; Boston study: [NIH National Cancer Institute (CA100679), (CA78609)].
PY - 2009/12/18
Y1 - 2009/12/18
N2 - Background: Sexual contact may be the means by which head and neck cancer patients are exposed to human papillomavirus (HPV). Methods: We undertook a pooled analysis of four population-based and four hospital-based case-control studies from the InternationalHead and Neck Cancer Epidemiology (INHANCE) consortium, with participants from Argentina, Australia, Brazil, Canada, Cuba, India, Italy, Spain, Poland, Puerto Rico, Russia and the USA. The study included 5642 head and neck cancer cases and 6069 controls. We calculated odds ratios (ORs) of associations between cancer and specific sexual behaviours, including practice of oral sex, number of lifetime sexual partners and oral sex partners, age at sexual debut, a history of same-sex contact and a history of oral-anal contact. Findings were stratified by sex and disease subsite. Results: Cancer of the oropharynx was associated with having a history of six or more lifetime sexual partners [OR=1.25, 95% confidence interval (CI) 1.01, 1.54] and four or more lifetime oral sex partners (OR=2.25, 95% CI 1.42, 3.58). Cancer of the tonsil was associated with four or more lifetime oral sex partners (OR=3.36, 95 % CI 1.32, 8.53), and, among men, with ever having oral sex (OR=1.59, 95% CI 1.09, 2.33) and with an earlier age at sexual debut (OR=2.36, 95% CI 1.37, 5.05). Cancer of the base of the tongue was associated with ever having oral sex among women (OR=4.32, 95% CI 1.06, 17.6), having two sexual partners in comparison with only one (OR=2.02, 95% CI 1.19, 3.46) and, among men, with a history of same-sex sexual contact (OR=8.89, 95% CI 2.14, 36.8). Conclusions: Sexual behaviours are associated with cancer risk at the head and neck cancer subsites that have previously been associated with HPV infection.
AB - Background: Sexual contact may be the means by which head and neck cancer patients are exposed to human papillomavirus (HPV). Methods: We undertook a pooled analysis of four population-based and four hospital-based case-control studies from the InternationalHead and Neck Cancer Epidemiology (INHANCE) consortium, with participants from Argentina, Australia, Brazil, Canada, Cuba, India, Italy, Spain, Poland, Puerto Rico, Russia and the USA. The study included 5642 head and neck cancer cases and 6069 controls. We calculated odds ratios (ORs) of associations between cancer and specific sexual behaviours, including practice of oral sex, number of lifetime sexual partners and oral sex partners, age at sexual debut, a history of same-sex contact and a history of oral-anal contact. Findings were stratified by sex and disease subsite. Results: Cancer of the oropharynx was associated with having a history of six or more lifetime sexual partners [OR=1.25, 95% confidence interval (CI) 1.01, 1.54] and four or more lifetime oral sex partners (OR=2.25, 95% CI 1.42, 3.58). Cancer of the tonsil was associated with four or more lifetime oral sex partners (OR=3.36, 95 % CI 1.32, 8.53), and, among men, with ever having oral sex (OR=1.59, 95% CI 1.09, 2.33) and with an earlier age at sexual debut (OR=2.36, 95% CI 1.37, 5.05). Cancer of the base of the tongue was associated with ever having oral sex among women (OR=4.32, 95% CI 1.06, 17.6), having two sexual partners in comparison with only one (OR=2.02, 95% CI 1.19, 3.46) and, among men, with a history of same-sex sexual contact (OR=8.89, 95% CI 2.14, 36.8). Conclusions: Sexual behaviours are associated with cancer risk at the head and neck cancer subsites that have previously been associated with HPV infection.
KW - Gay men
KW - Head and neck cancer
KW - Homosexual
KW - Oropharyngeal neoplasms
KW - Pooled analyses
KW - Risk factors
KW - Sexual practices
UR - http://www.scopus.com/inward/record.url?scp=77952312776&partnerID=8YFLogxK
U2 - 10.1093/ije/dyp350
DO - 10.1093/ije/dyp350
M3 - Article
C2 - 20022926
AN - SCOPUS:77952312776
SN - 0300-5771
VL - 39
SP - 166
EP - 181
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 1
ER -