Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task

Tracy Butler; Julianne Imperato-McGinley; Hong Pan; Daniel Voyer; Amy Christine Cunningham-Bussel; Luke Chang; Yuan Shan Zhu; Juan J. Cordero; Emily Stern; David Silbersweig

doi:10.1002/hbm.20340

Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task

Tracy Butler
, Julianne Imperato-McGinley
, Hong Pan
, Daniel Voyer
, Amy Christine Cunningham-Bussel
, Luke Chang
, Yuan Shan Zhu
, Juan J. Cordero
, Emily Stern
, David Silbersweig

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Ventral anterior cingulate cortex (vACC) is a highly interconnected brain region considered to reflect the sometimes competing demands of cognition and emotion. A reciprocal relationship between vACC and dorsal ACC (dACC) may play a role in maintaining this balance between cognitive and emotional processing. Using functional MRI in association with a cognitively-demanding visuospatial task (mental rotation), we found that only women demonstrated vACC suppression and inverse functional connectivity with dACC. Sex differences in vACC functioning - previously described under conditions of negative emotion - are extended here to cognition. Consideration of participant sex is essential to understanding the role of vACC in cognitive and emotional processing.

Original language	English
Pages (from-to)	1206-1212
Number of pages	7
Journal	Human Brain Mapping
Volume	28
Issue number	11
DOIs	https://doi.org/10.1002/hbm.20340
State	Published - Nov 2007
Externally published	Yes

Keywords

Brodmann area 25
Functional connectivity
Functional neuroimaging
Gender
Mental rotation
Sex differences
Subgenual
Ventromedial prefrontal cortex
Visuospatial
fMRI

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10.1002/hbm.20340

Cite this

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title = "Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task",

abstract = "Ventral anterior cingulate cortex (vACC) is a highly interconnected brain region considered to reflect the sometimes competing demands of cognition and emotion. A reciprocal relationship between vACC and dorsal ACC (dACC) may play a role in maintaining this balance between cognitive and emotional processing. Using functional MRI in association with a cognitively-demanding visuospatial task (mental rotation), we found that only women demonstrated vACC suppression and inverse functional connectivity with dACC. Sex differences in vACC functioning - previously described under conditions of negative emotion - are extended here to cognition. Consideration of participant sex is essential to understanding the role of vACC in cognitive and emotional processing.",

keywords = "Brodmann area 25, Functional connectivity, Functional neuroimaging, Gender, Mental rotation, Sex differences, Subgenual, Ventromedial prefrontal cortex, Visuospatial, fMRI",

author = "Tracy Butler and Julianne Imperato-McGinley and Hong Pan and Daniel Voyer and Cunningham-Bussel, \{Amy Christine\} and Luke Chang and Zhu, \{Yuan Shan\} and Cordero, \{Juan J.\} and Emily Stern and David Silbersweig",

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doi = "10.1002/hbm.20340",

language = "English",

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AU - Butler, Tracy

AU - Imperato-McGinley, Julianne

AU - Pan, Hong

AU - Voyer, Daniel

AU - Cunningham-Bussel, Amy Christine

AU - Chang, Luke

AU - Zhu, Yuan Shan

AU - Cordero, Juan J.

AU - Stern, Emily

AU - Silbersweig, David

PY - 2007/11

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AB - Ventral anterior cingulate cortex (vACC) is a highly interconnected brain region considered to reflect the sometimes competing demands of cognition and emotion. A reciprocal relationship between vACC and dorsal ACC (dACC) may play a role in maintaining this balance between cognitive and emotional processing. Using functional MRI in association with a cognitively-demanding visuospatial task (mental rotation), we found that only women demonstrated vACC suppression and inverse functional connectivity with dACC. Sex differences in vACC functioning - previously described under conditions of negative emotion - are extended here to cognition. Consideration of participant sex is essential to understanding the role of vACC in cognitive and emotional processing.

KW - Brodmann area 25

KW - Functional connectivity

KW - Functional neuroimaging

KW - Gender

KW - Mental rotation

KW - Sex differences

KW - Subgenual

KW - Ventromedial prefrontal cortex

KW - Visuospatial

KW - fMRI

UR - https://www.scopus.com/pages/publications/35948969333

U2 - 10.1002/hbm.20340

DO - 10.1002/hbm.20340

M3 - Article

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SP - 1206

EP - 1212

JO - Human Brain Mapping

JF - Human Brain Mapping

IS - 11

ER -

Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task

Abstract

Keywords

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