Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task

Tracy Butler, Julianne Imperato-McGinley, Hong Pan, Daniel Voyer, Amy Christine Cunningham-Bussel, Luke Chang, Yuan Shan Zhu, Juan J. Cordero, Emily Stern, David Silbersweig

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Ventral anterior cingulate cortex (vACC) is a highly interconnected brain region considered to reflect the sometimes competing demands of cognition and emotion. A reciprocal relationship between vACC and dorsal ACC (dACC) may play a role in maintaining this balance between cognitive and emotional processing. Using functional MRI in association with a cognitively-demanding visuospatial task (mental rotation), we found that only women demonstrated vACC suppression and inverse functional connectivity with dACC. Sex differences in vACC functioning - previously described under conditions of negative emotion - are extended here to cognition. Consideration of participant sex is essential to understanding the role of vACC in cognitive and emotional processing.

Original languageEnglish
Pages (from-to)1206-1212
Number of pages7
JournalHuman Brain Mapping
Volume28
Issue number11
DOIs
StatePublished - Nov 2007
Externally publishedYes

Keywords

  • Brodmann area 25
  • Functional connectivity
  • Functional neuroimaging
  • Gender
  • Mental rotation
  • Sex differences
  • Subgenual
  • Ventromedial prefrontal cortex
  • Visuospatial
  • fMRI

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