TY - JOUR
T1 - Sex-Related Outcomes of Medical, Percutaneous, and Surgical Interventions for Coronary Artery Disease
T2 - JACC Focus Seminar 3/7
AU - Gaudino, Mario
AU - Di Franco, Antonino
AU - Cao, Davide
AU - Giustino, Gennaro
AU - Bairey Merz, C. Noel
AU - Fremes, Stephen E.
AU - Kirtane, Ajay J.
AU - Kunadian, Vijay
AU - Lawton, Jennifer S.
AU - Masterson Creber, Ruth Marie
AU - Sandner, Sigrid
AU - Vogel, Birgit
AU - Zwischenberger, Brittany A.
AU - Dangas, George D.
AU - Mehran, Roxana
N1 - Publisher Copyright:
© 2022 American College of Cardiology Foundation
PY - 2022/4/12
Y1 - 2022/4/12
N2 - Biological and sociocultural differences between men and women are complex and likely account for most of the variations in the epidemiology and treatment outcomes of coronary artery disease (CAD) between the 2 sexes. Worse outcomes in women have been described following both conservative and invasive treatments of CAD. For example, increased levels of residual platelet reactivity during treatment with antiplatelet drugs, higher rates of adverse cardiovascular outcomes following percutaneous coronary revascularization, and higher operative and long-term mortality after coronary bypass surgery have been reported in women compared with in men. Despite the growing recognition of sex-specific determinants of outcomes, representation of women in clinical studies remains low and sex-specific management strategies are generally not provided in guidelines. This review summarizes the current evidence on sex-related differences in patients with CAD, focusing on the differential outcomes following medical therapy, percutaneous coronary interventions, and coronary artery bypass surgery.
AB - Biological and sociocultural differences between men and women are complex and likely account for most of the variations in the epidemiology and treatment outcomes of coronary artery disease (CAD) between the 2 sexes. Worse outcomes in women have been described following both conservative and invasive treatments of CAD. For example, increased levels of residual platelet reactivity during treatment with antiplatelet drugs, higher rates of adverse cardiovascular outcomes following percutaneous coronary revascularization, and higher operative and long-term mortality after coronary bypass surgery have been reported in women compared with in men. Despite the growing recognition of sex-specific determinants of outcomes, representation of women in clinical studies remains low and sex-specific management strategies are generally not provided in guidelines. This review summarizes the current evidence on sex-related differences in patients with CAD, focusing on the differential outcomes following medical therapy, percutaneous coronary interventions, and coronary artery bypass surgery.
KW - coronary artery disease
KW - sex
KW - women
UR - http://www.scopus.com/inward/record.url?scp=85127012918&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2021.07.066
DO - 10.1016/j.jacc.2021.07.066
M3 - Review article
C2 - 35393023
AN - SCOPUS:85127012918
SN - 0735-1097
VL - 79
SP - 1407
EP - 1425
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 14
ER -