Sex differences in the human connectome: 4-Tesla high angular resolution diffusion imaging (HARDI) tractography in 234 young adult twins

Neda Jahanshad; Iman Aganj; Christophe Lenglet; Anand Joshi; Yan Jin; Marina Barysheva; Katie L. McMahon; Greig I. De Zubicaray; Nicholas G. Martin; Margaret J. Wright; Arthur W. Toga; Guillermo Sapiro; Paul M. Thompson

doi:10.1109/ISBI.2011.5872558

Sex differences in the human connectome: 4-Tesla high angular resolution diffusion imaging (HARDI) tractography in 234 young adult twins

Neda Jahanshad
, Iman Aganj
, Christophe Lenglet
, Anand Joshi
, Yan Jin
, Marina Barysheva
, Katie L. McMahon
, Greig I. De Zubicaray
, Nicholas G. Martin
, Margaret J. Wright
, Arthur W. Toga
, Guillermo Sapiro
, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

38 Scopus citations

Abstract

Cortical connectivity is associated with cognitive and behavioral traits that are thought to vary between sexes. Using high-angular resolution diffusion imaging at 4 Tesla, we scanned 234 young adult twins and siblings (mean age: 23.4 2.0 SD years) with 94 diffusion-encoding directions. We applied a novel Hough transform method to extract fiber tracts throughout the entire brain, based on fields of constant solid angle orientation distribution functions (ODFs). Cortical surfaces were generated from each subject's 3D T1-weighted structural MRI scan, and tracts were aligned to the anatomy. Network analysis revealed the proportions of fibers interconnecting 5 key subregions of the frontal cortex, including connections between hemispheres. We found significant sex differences (147 women/87 men) in the proportions of fibers connecting contralateral superior frontal cortices. Interhemispheric connectivity was greater in women, in line with long-standing theories of hemispheric specialization. These findings may be relevant for ongoing studies of the human connectome.

Original language	English
Title of host publication	2011 8th IEEE International Symposium on Biomedical Imaging
Subtitle of host publication	From Nano to Macro, ISBI'11
Publisher	IEEE Computer Society
Pages	939-943
Number of pages	5
ISBN (Print)	9781424441280
DOIs	https://doi.org/10.1109/ISBI.2011.5872558
State	Published - 2011
Externally published	Yes
Event	8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2011 - Chicago, IL, United States Duration: 30 Mar 2011 → 2 Apr 2011

Publication series

Name	Proceedings - International Symposium on Biomedical Imaging
ISSN (Print)	1945-7928
ISSN (Electronic)	1945-8452

Conference

Conference	8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2011
Country/Territory	United States
City	Chicago, IL
Period	30/03/11 → 2/04/11

Keywords

high angular resolution diffusion imaging (HARDI)
human connectome
inter-hemispheric connectivity
network analysis
tractography

Access to Document

10.1109/ISBI.2011.5872558

Cite this

Jahanshad, N., Aganj, I., Lenglet, C., Joshi, A., Jin, Y., Barysheva, M., McMahon, K. L., De Zubicaray, G. I., Martin, N. G., Wright, M. J., Toga, A. W., Sapiro, G., & Thompson, P. M. (2011). Sex differences in the human connectome: 4-Tesla high angular resolution diffusion imaging (HARDI) tractography in 234 young adult twins. In 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11 (pp. 939-943). Article 5872558 (Proceedings - International Symposium on Biomedical Imaging). IEEE Computer Society. https://doi.org/10.1109/ISBI.2011.5872558

Jahanshad, Neda ; Aganj, Iman ; Lenglet, Christophe et al. / Sex differences in the human connectome : 4-Tesla high angular resolution diffusion imaging (HARDI) tractography in 234 young adult twins. 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11. IEEE Computer Society, 2011. pp. 939-943 (Proceedings - International Symposium on Biomedical Imaging).

@inproceedings{3effe8b17020454fa69b1da2c7728a67,

title = "Sex differences in the human connectome: 4-Tesla high angular resolution diffusion imaging (HARDI) tractography in 234 young adult twins",

abstract = "Cortical connectivity is associated with cognitive and behavioral traits that are thought to vary between sexes. Using high-angular resolution diffusion imaging at 4 Tesla, we scanned 234 young adult twins and siblings (mean age: 23.4 2.0 SD years) with 94 diffusion-encoding directions. We applied a novel Hough transform method to extract fiber tracts throughout the entire brain, based on fields of constant solid angle orientation distribution functions (ODFs). Cortical surfaces were generated from each subject's 3D T1-weighted structural MRI scan, and tracts were aligned to the anatomy. Network analysis revealed the proportions of fibers interconnecting 5 key subregions of the frontal cortex, including connections between hemispheres. We found significant sex differences (147 women/87 men) in the proportions of fibers connecting contralateral superior frontal cortices. Interhemispheric connectivity was greater in women, in line with long-standing theories of hemispheric specialization. These findings may be relevant for ongoing studies of the human connectome.",

keywords = "high angular resolution diffusion imaging (HARDI), human connectome, inter-hemispheric connectivity, network analysis, tractography",

author = "Neda Jahanshad and Iman Aganj and Christophe Lenglet and Anand Joshi and Yan Jin and Marina Barysheva and McMahon, \{Katie L.\} and \{De Zubicaray\}, \{Greig I.\} and Martin, \{Nicholas G.\} and Wright, \{Margaret J.\} and Toga, \{Arthur W.\} and Guillermo Sapiro and Thompson, \{Paul M.\}",

year = "2011",

doi = "10.1109/ISBI.2011.5872558",

language = "English",

isbn = "9781424441280",

series = "Proceedings - International Symposium on Biomedical Imaging",

publisher = "IEEE Computer Society",

pages = "939--943",

booktitle = "2011 8th IEEE International Symposium on Biomedical Imaging",

address = "United States",

note = "8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2011 ; Conference date: 30-03-2011 Through 02-04-2011",

}

Jahanshad, N, Aganj, I, Lenglet, C, Joshi, A, Jin, Y, Barysheva, M, McMahon, KL, De Zubicaray, GI, Martin, NG, Wright, MJ, Toga, AW, Sapiro, G & Thompson, PM 2011, Sex differences in the human connectome: 4-Tesla high angular resolution diffusion imaging (HARDI) tractography in 234 young adult twins. in 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11., 5872558, Proceedings - International Symposium on Biomedical Imaging, IEEE Computer Society, pp. 939-943, 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2011, Chicago, IL, United States, 30/03/11. https://doi.org/10.1109/ISBI.2011.5872558

Sex differences in the human connectome: 4-Tesla high angular resolution diffusion imaging (HARDI) tractography in 234 young adult twins. / Jahanshad, Neda; Aganj, Iman; Lenglet, Christophe et al.
2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11. IEEE Computer Society, 2011. p. 939-943 5872558 (Proceedings - International Symposium on Biomedical Imaging).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

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T2 - 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2011

AU - Jahanshad, Neda

AU - Aganj, Iman

AU - Lenglet, Christophe

AU - Joshi, Anand

AU - Jin, Yan

AU - Barysheva, Marina

AU - McMahon, Katie L.

AU - De Zubicaray, Greig I.

AU - Martin, Nicholas G.

AU - Wright, Margaret J.

AU - Toga, Arthur W.

AU - Sapiro, Guillermo

AU - Thompson, Paul M.

PY - 2011

Y1 - 2011

N2 - Cortical connectivity is associated with cognitive and behavioral traits that are thought to vary between sexes. Using high-angular resolution diffusion imaging at 4 Tesla, we scanned 234 young adult twins and siblings (mean age: 23.4 2.0 SD years) with 94 diffusion-encoding directions. We applied a novel Hough transform method to extract fiber tracts throughout the entire brain, based on fields of constant solid angle orientation distribution functions (ODFs). Cortical surfaces were generated from each subject's 3D T1-weighted structural MRI scan, and tracts were aligned to the anatomy. Network analysis revealed the proportions of fibers interconnecting 5 key subregions of the frontal cortex, including connections between hemispheres. We found significant sex differences (147 women/87 men) in the proportions of fibers connecting contralateral superior frontal cortices. Interhemispheric connectivity was greater in women, in line with long-standing theories of hemispheric specialization. These findings may be relevant for ongoing studies of the human connectome.

AB - Cortical connectivity is associated with cognitive and behavioral traits that are thought to vary between sexes. Using high-angular resolution diffusion imaging at 4 Tesla, we scanned 234 young adult twins and siblings (mean age: 23.4 2.0 SD years) with 94 diffusion-encoding directions. We applied a novel Hough transform method to extract fiber tracts throughout the entire brain, based on fields of constant solid angle orientation distribution functions (ODFs). Cortical surfaces were generated from each subject's 3D T1-weighted structural MRI scan, and tracts were aligned to the anatomy. Network analysis revealed the proportions of fibers interconnecting 5 key subregions of the frontal cortex, including connections between hemispheres. We found significant sex differences (147 women/87 men) in the proportions of fibers connecting contralateral superior frontal cortices. Interhemispheric connectivity was greater in women, in line with long-standing theories of hemispheric specialization. These findings may be relevant for ongoing studies of the human connectome.

KW - high angular resolution diffusion imaging (HARDI)

KW - human connectome

KW - inter-hemispheric connectivity

KW - network analysis

KW - tractography

UR - https://www.scopus.com/pages/publications/80055044382

U2 - 10.1109/ISBI.2011.5872558

DO - 10.1109/ISBI.2011.5872558

M3 - Conference contribution

AN - SCOPUS:80055044382

SN - 9781424441280

T3 - Proceedings - International Symposium on Biomedical Imaging

SP - 939

EP - 943

BT - 2011 8th IEEE International Symposium on Biomedical Imaging

PB - IEEE Computer Society

Y2 - 30 March 2011 through 2 April 2011

ER -

Jahanshad N, Aganj I, Lenglet C, Joshi A, Jin Y, Barysheva M et al. Sex differences in the human connectome: 4-Tesla high angular resolution diffusion imaging (HARDI) tractography in 234 young adult twins. In 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11. IEEE Computer Society. 2011. p. 939-943. 5872558. (Proceedings - International Symposium on Biomedical Imaging). doi: 10.1109/ISBI.2011.5872558

Sex differences in the human connectome: 4-Tesla high angular resolution diffusion imaging (HARDI) tractography in 234 young adult twins

Abstract

Publication series

Conference

Keywords

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