@article{6ba8ce3964c74fcb8a892db795a04d80,
title = "Sex differences in M2 polarization, chemokine and IL-4 receptors in monocytes and macrophages from asthmatics",
abstract = "Allergic asthma affects more women than men. It is mediated partially by IL-4/IL-13-driven polarization of monocyte-derived macrophages in the lung. We tested whether sex differences in asthma are due to differential IL-4 responsiveness and/or chemokine receptor expression in monocytes and monocyte-derived macrophages from healthy and allergic asthmatic men and women. We found female cells expressed M2 genes more robustly following IL-4 stimulation than male cells, as did cells from asthmatics than those from healthy controls. This likely resulted from increased expression of γC, part of the type I IL-4 receptor, and reduced IL-4–induced SOCS1, a negative regulator of IL-4 signaling, in asthmatic compared to healthy macrophages. Monocytes from asthmatic women expressed more CX3CR1, which enhances macrophage survival. Our findings highlight how sex differences in IL-4 responsiveness and chemokine receptor expression may affect monocyte recruitment and macrophage polarization in asthma, potentially leading to new sex-specific therapies to manage the disease.",
keywords = "Allergic lung inflammation, Alveolar macrophages, Asthma, Cell recruitment, Chemokine, Hormones, IL-4, Monocytes, Sex differences",
author = "Mireya Becerra-D{\'i}az and Lerner, {Andrew D.} and Yu, {Diana H.} and Thiboutot, {Jeffrey P.} and Liu, {Mark C.} and Yarmus, {Lonny B.} and Sonali Bose and Heller, {Nicola M.}",
note = "Funding Information: The authors extend their gratitude to the University of Virginia Center for Research in Reproduction's Ligand Assay and Analysis Core for serum sex hormone measurements. Support for statistical analysis was made possible by the Johns Hopkins Institute for Clinical and Translational Research (ICTR), which is funded in part by grant number UL1 TR003098 from the National Center for Advancing Translational Sciences (NCATS), a component of the NIH, and NIH Roadmap for Medical Research. We thank Claire Levine, ELS, and Melina V. Jones, Ph.D. for help in editing the manuscript. Funding Information: The authors extend their gratitude to the University of Virginia Center for Research in Reproduction{\textquoteright}s Ligand Assay and Analysis Core for serum sex hormone measurements. Support for statistical analysis was made possible by the Johns Hopkins Institute for Clinical and Translational Research (ICTR), which is funded in part by grant number UL1 TR003098 from the National Center for Advancing Translational Sciences (NCATS), a component of the NIH, and NIH Roadmap for Medical Research. We thank Claire Levine, ELS, and Melina V. Jones, Ph.D., for help in editing the manuscript. Funding Information: This research was supported by funding from National Institutes of Health Grant R01 HL124477 (to N.M.H.). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = feb,
doi = "10.1016/j.cellimm.2020.104252",
language = "English",
volume = "360",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
}