Sex differences in lipid levels, thrombus formation, and response to pravastatin

G. Dangas, A. M. Cohen, A. H. Unger, P. Meraj, J. J. Badimon, J. A. Ambrose

Research output: Contribution to journalReview articlepeer-review

Abstract

We prospectively studied 29 women and 28 men treated for elevated low-density lipoprotein cholesterol levels with a 6-month course of pravastatin therapy to determine sex-related outcomes. Despite higher high-density lipoprotein levels and a lower incidence of coronary artery disease, women had increased thrombin generation. Otherwise, baseline hemostatic profiles were similar. Pravastatin therapy corrected this difference in thrombin generation and significantly reduced blood thrombogenicity in both sexes.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalCardiology Review
Volume17
Issue number8
StatePublished - 2000

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