Sex differences in cytokine production following West Nile virus infection: Implications for symptom manifestation

Kevin W. Hoffman; Jakleen J. Lee; Gregory A. Foster; David Krysztof; Susan L. Stramer; Jean K. Lim

doi:10.1093/femspd/ftz016

Sex differences in cytokine production following West Nile virus infection: Implications for symptom manifestation

Kevin W. Hoffman, Jakleen J. Lee, Gregory A. Foster, David Krysztof, Susan L. Stramer, Jean K. Lim

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

West Nile virus (WNV) infection outcomes vary among individuals, with most infections resulting in asymptomatic or mild flu-like symptoms. We previously reported an association between early cytokine production and symptom outcome following WNV infection in US blood donors. In this meta-analysis, we found that WNV-infected females reported more symptoms than WNV-infected males, despite similar initial viremia and type I interferon responses. As the infection progressed, males exhibited a protracted cytokine response—marked by sustained CCL2 (MCP-1), CCL11 (eotaxin-1), CXCL10 (IP-10) and IL-15—that was absent in females. Our results suggest that sex differences may be a factor in sustaining WNV immunity.

Original language	English
Journal	Pathogens and Disease
Volume	77
Issue number	2
DOIs	https://doi.org/10.1093/femspd/ftz016
State	Published - 1 Mar 2019

Keywords

Blood bank
Blood donations
Clinical outcome
Cytokines
Sex differences
Susceptibility

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10.1093/femspd/ftz016

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title = "Sex differences in cytokine production following West Nile virus infection: Implications for symptom manifestation",

abstract = "West Nile virus (WNV) infection outcomes vary among individuals, with most infections resulting in asymptomatic or mild flu-like symptoms. We previously reported an association between early cytokine production and symptom outcome following WNV infection in US blood donors. In this meta-analysis, we found that WNV-infected females reported more symptoms than WNV-infected males, despite similar initial viremia and type I interferon responses. As the infection progressed, males exhibited a protracted cytokine response—marked by sustained CCL2 (MCP-1), CCL11 (eotaxin-1), CXCL10 (IP-10) and IL-15—that was absent in females. Our results suggest that sex differences may be a factor in sustaining WNV immunity.",

keywords = "Blood bank, Blood donations, Clinical outcome, Cytokines, Sex differences, Susceptibility",

author = "Hoffman, {Kevin W.} and Lee, {Jakleen J.} and Foster, {Gregory A.} and David Krysztof and Stramer, {Susan L.} and Lim, {Jean K.}",

note = "Funding Information: This work was supported by the National Institute of Allergy and Infectious Diseases and the National Institutes of Health [R01 AI108715-01 and T32 AI007647]. Publisher Copyright: {\textcopyright} FEMS 2019. All rights reserved.",

year = "2019",

month = mar,

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doi = "10.1093/femspd/ftz016",

language = "English",

volume = "77",

journal = "Pathogens and Disease",

issn = "2049-632X",

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TY - JOUR

T1 - Sex differences in cytokine production following West Nile virus infection

T2 - Implications for symptom manifestation

AU - Hoffman, Kevin W.

AU - Lee, Jakleen J.

AU - Foster, Gregory A.

AU - Krysztof, David

AU - Stramer, Susan L.

AU - Lim, Jean K.

N1 - Funding Information: This work was supported by the National Institute of Allergy and Infectious Diseases and the National Institutes of Health [R01 AI108715-01 and T32 AI007647]. Publisher Copyright: © FEMS 2019. All rights reserved.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - West Nile virus (WNV) infection outcomes vary among individuals, with most infections resulting in asymptomatic or mild flu-like symptoms. We previously reported an association between early cytokine production and symptom outcome following WNV infection in US blood donors. In this meta-analysis, we found that WNV-infected females reported more symptoms than WNV-infected males, despite similar initial viremia and type I interferon responses. As the infection progressed, males exhibited a protracted cytokine response—marked by sustained CCL2 (MCP-1), CCL11 (eotaxin-1), CXCL10 (IP-10) and IL-15—that was absent in females. Our results suggest that sex differences may be a factor in sustaining WNV immunity.

AB - West Nile virus (WNV) infection outcomes vary among individuals, with most infections resulting in asymptomatic or mild flu-like symptoms. We previously reported an association between early cytokine production and symptom outcome following WNV infection in US blood donors. In this meta-analysis, we found that WNV-infected females reported more symptoms than WNV-infected males, despite similar initial viremia and type I interferon responses. As the infection progressed, males exhibited a protracted cytokine response—marked by sustained CCL2 (MCP-1), CCL11 (eotaxin-1), CXCL10 (IP-10) and IL-15—that was absent in females. Our results suggest that sex differences may be a factor in sustaining WNV immunity.

KW - Blood bank

KW - Blood donations

KW - Clinical outcome

KW - Cytokines

KW - Sex differences

KW - Susceptibility

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DO - 10.1093/femspd/ftz016

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SN - 2049-632X

VL - 77

JO - Pathogens and Disease

JF - Pathogens and Disease

IS - 2

ER -

Sex differences in cytokine production following West Nile virus infection: Implications for symptom manifestation

Abstract

Keywords

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