TY - JOUR
T1 - Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease
T2 - Findings from three well-characterized cohorts
AU - Alzheimer's Disease Neuroimaging Initiative
AU - the Australian Imaging, Biomarker and Lifestyle study of ageing
AU - the Harvard Aging Brain Study
AU - Buckley, Rachel F.
AU - Mormino, Elizabeth C.
AU - Amariglio, Rebecca E.
AU - Properzi, Michael J.
AU - Rabin, Jennifer S.
AU - Lim, Yen Ying
AU - Papp, Kathryn V.
AU - Jacobs, Heidi I.L.
AU - Burnham, Samantha
AU - Hanseeuw, Bernard J.
AU - Doré, Vincent
AU - Dobson, Annette
AU - Masters, Colin L.
AU - Waller, Michael
AU - Rowe, Christopher C.
AU - Maruff, Paul
AU - Donohue, Michael C.
AU - Rentz, Dorene M.
AU - Kirn, Dylan
AU - Hedden, Trey
AU - Chhatwal, Jasmeer
AU - Schultz, Aaron P.
AU - Johnson, Keith A.
AU - Villemagne, Victor L.
AU - Sperling, Reisa A.
N1 - Publisher Copyright:
© 2018 the Alzheimer's Association
PY - 2018/9
Y1 - 2018/9
N2 - Introduction: Our objective was to investigate the effect of sex on cognitive decline within the context of amyloid β (Aβ) burden and apolipoprotein E genotype. Methods: We analyzed sex-specific effects on Aβ-positron emission tomography, apolipoprotein, and rates of change on the Preclinical Alzheimer Cognitive Composite-5 across three cohorts, such as the Alzheimer's Disease Neuroimaging Initiative, Australian Imaging, Biomarker and Lifestyle, and Harvard Aging Brain Study (n = 755; clinical dementia rating = 0; age (standard deviation) = 73.6 (6.5); female = 55%). Mixed-effects models of cognitive change by sex, Aβ-positron emission tomography, and apolipoprotein ε4 were examined with quadratic time effects over a median of 4 years of follow-up. Results: Apolipoprotein ε4 prevalence and Aβ burden did not differ by sex. Sex did not directly influence cognitive decline. Females with higher Aβ exhibited faster decline than males. Post hoc contrasts suggested that females who were Aβ and apolipoprotein ε4 positive declined faster than their male counterparts. Discussion: Although Aβ did not differ by sex, cognitive decline was greater in females with higher Aβ. Our findings suggest that sex may play a modifying role on risk of Alzheimer's disease–related cognitive decline.
AB - Introduction: Our objective was to investigate the effect of sex on cognitive decline within the context of amyloid β (Aβ) burden and apolipoprotein E genotype. Methods: We analyzed sex-specific effects on Aβ-positron emission tomography, apolipoprotein, and rates of change on the Preclinical Alzheimer Cognitive Composite-5 across three cohorts, such as the Alzheimer's Disease Neuroimaging Initiative, Australian Imaging, Biomarker and Lifestyle, and Harvard Aging Brain Study (n = 755; clinical dementia rating = 0; age (standard deviation) = 73.6 (6.5); female = 55%). Mixed-effects models of cognitive change by sex, Aβ-positron emission tomography, and apolipoprotein ε4 were examined with quadratic time effects over a median of 4 years of follow-up. Results: Apolipoprotein ε4 prevalence and Aβ burden did not differ by sex. Sex did not directly influence cognitive decline. Females with higher Aβ exhibited faster decline than males. Post hoc contrasts suggested that females who were Aβ and apolipoprotein ε4 positive declined faster than their male counterparts. Discussion: Although Aβ did not differ by sex, cognitive decline was greater in females with higher Aβ. Our findings suggest that sex may play a modifying role on risk of Alzheimer's disease–related cognitive decline.
KW - APOE
KW - Amyloid
KW - Cognitive decline
KW - Gender
KW - Preclinical Alzheimer's disease
KW - Sex
UR - http://www.scopus.com/inward/record.url?scp=85050138444&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2018.04.010
DO - 10.1016/j.jalz.2018.04.010
M3 - Article
C2 - 29803541
AN - SCOPUS:85050138444
SN - 1552-5260
VL - 14
SP - 1193
EP - 1203
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 9
ER -