Severe Mpox Among People With Advanced Human Immunodeficiency Virus Receiving Prolonged Tecovirimat in New York City

Elizabeth A. Garcia; Mary M.K. Foote; Tristan D. McPherson; Maura K. Lash; Amma N. Bosompem; Alyssa Bouscaren; Justin Chan; Madeline A. Dilorenzo; Dennis Feihel; Randal C. Fowler; Vani Gandhi; Elizabeth R. Jenny-Avital; Erik J. Kopping; Dana Mazo; Jacob McLean; Ofole Mgbako; Mark N. Sayegh; Raphael N. Shaw; Michelle Su; Jeanne Sullivan Meissner; Jade C. Wang; Wendy Wen; John C. Winters; Cosmina B. Zeana; Jason Zucker; Marcia Wong

doi:10.1093/ofid/ofae294

Severe Mpox Among People With Advanced Human Immunodeficiency Virus Receiving Prolonged Tecovirimat in New York City

Elizabeth A. Garcia, Mary M.K. Foote, Tristan D. McPherson, Maura K. Lash, Amma N. Bosompem, Alyssa Bouscaren, Justin Chan, Madeline A. Dilorenzo, Dennis Feihel, Randal C. Fowler, Vani Gandhi, Elizabeth R. Jenny-Avital, Erik J. Kopping, Dana Mazo, Jacob McLean, Ofole Mgbako, Mark N. Sayegh, Raphael N. Shaw, Michelle Su, Jeanne Sullivan MeissnerJade C. Wang, Wendy Wen, John C. Winters, Cosmina B. Zeana, Jason Zucker, Marcia Wong

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3 Scopus citations

Abstract

Severe mpox has been observed in people with advanced human immunodeficiency virus (HIV). We describe clinical outcomes of 13 patients with advanced HIV (CD4 <200 cells/μL), severe mpox, and multiorgan involvement. Despite extended tecovirimat courses and additional agents, including vaccinia immune globulin, cidofovir, and brincidofovir, this group experienced prolonged hospitalizations and high mortality.

Original language	English
Article number	ofae294
Journal	Open Forum Infectious Diseases
Volume	11
Issue number	6
DOIs	https://doi.org/10.1093/ofid/ofae294
State	Published - 1 Jun 2024

Keywords

HIV/AIDS
immunocompromise
mortality
mpox treatment
tecovirimat

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10.1093/ofid/ofae294

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Garcia, E. A., Foote, M. M. K., McPherson, T. D., Lash, M. K., Bosompem, A. N., Bouscaren, A., Chan, J., Dilorenzo, M. A., Feihel, D., Fowler, R. C., Gandhi, V., Jenny-Avital, E. R., Kopping, E. J., Mazo, D., McLean, J., Mgbako, O., Sayegh, M. N., Shaw, R. N., Su, M., ... Wong, M. (2024). Severe Mpox Among People With Advanced Human Immunodeficiency Virus Receiving Prolonged Tecovirimat in New York City. Open Forum Infectious Diseases, 11(6), Article ofae294. https://doi.org/10.1093/ofid/ofae294

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title = "Severe Mpox Among People With Advanced Human Immunodeficiency Virus Receiving Prolonged Tecovirimat in New York City",

abstract = "Severe mpox has been observed in people with advanced human immunodeficiency virus (HIV). We describe clinical outcomes of 13 patients with advanced HIV (CD4 <200 cells/μL), severe mpox, and multiorgan involvement. Despite extended tecovirimat courses and additional agents, including vaccinia immune globulin, cidofovir, and brincidofovir, this group experienced prolonged hospitalizations and high mortality.",

keywords = "HIV/AIDS, immunocompromise, mortality, mpox treatment, tecovirimat",

author = "Garcia, \{Elizabeth A.\} and Foote, \{Mary M.K.\} and McPherson, \{Tristan D.\} and Lash, \{Maura K.\} and Bosompem, \{Amma N.\} and Alyssa Bouscaren and Justin Chan and Dilorenzo, \{Madeline A.\} and Dennis Feihel and Fowler, \{Randal C.\} and Vani Gandhi and Jenny-Avital, \{Elizabeth R.\} and Kopping, \{Erik J.\} and Dana Mazo and Jacob McLean and Ofole Mgbako and Sayegh, \{Mark N.\} and Shaw, \{Raphael N.\} and Michelle Su and Meissner, \{Jeanne Sullivan\} and Wang, \{Jade C.\} and Wendy Wen and Winters, \{John C.\} and Zeana, \{Cosmina B.\} and Jason Zucker and Marcia Wong",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2024",

month = jun,

day = "1",

doi = "10.1093/ofid/ofae294",

language = "English",

volume = "11",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

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Garcia, EA, Foote, MMK, McPherson, TD, Lash, MK, Bosompem, AN, Bouscaren, A, Chan, J, Dilorenzo, MA, Feihel, D, Fowler, RC, Gandhi, V, Jenny-Avital, ER, Kopping, EJ, Mazo, D, McLean, J, Mgbako, O, Sayegh, MN, Shaw, RN, Su, M, Meissner, JS, Wang, JC, Wen, W, Winters, JC, Zeana, CB, Zucker, J & Wong, M 2024, 'Severe Mpox Among People With Advanced Human Immunodeficiency Virus Receiving Prolonged Tecovirimat in New York City', Open Forum Infectious Diseases, vol. 11, no. 6, ofae294. https://doi.org/10.1093/ofid/ofae294

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T1 - Severe Mpox Among People With Advanced Human Immunodeficiency Virus Receiving Prolonged Tecovirimat in New York City

AU - Garcia, Elizabeth A.

AU - Foote, Mary M.K.

AU - McPherson, Tristan D.

AU - Lash, Maura K.

AU - Bosompem, Amma N.

AU - Bouscaren, Alyssa

AU - Chan, Justin

AU - Dilorenzo, Madeline A.

AU - Feihel, Dennis

AU - Fowler, Randal C.

AU - Gandhi, Vani

AU - Jenny-Avital, Elizabeth R.

AU - Kopping, Erik J.

AU - Mazo, Dana

AU - McLean, Jacob

AU - Mgbako, Ofole

AU - Sayegh, Mark N.

AU - Shaw, Raphael N.

AU - Su, Michelle

AU - Meissner, Jeanne Sullivan

AU - Wang, Jade C.

AU - Wen, Wendy

AU - Winters, John C.

AU - Zeana, Cosmina B.

AU - Zucker, Jason

AU - Wong, Marcia

PY - 2024/6/1

Y1 - 2024/6/1

N2 - Severe mpox has been observed in people with advanced human immunodeficiency virus (HIV). We describe clinical outcomes of 13 patients with advanced HIV (CD4 <200 cells/μL), severe mpox, and multiorgan involvement. Despite extended tecovirimat courses and additional agents, including vaccinia immune globulin, cidofovir, and brincidofovir, this group experienced prolonged hospitalizations and high mortality.

AB - Severe mpox has been observed in people with advanced human immunodeficiency virus (HIV). We describe clinical outcomes of 13 patients with advanced HIV (CD4 <200 cells/μL), severe mpox, and multiorgan involvement. Despite extended tecovirimat courses and additional agents, including vaccinia immune globulin, cidofovir, and brincidofovir, this group experienced prolonged hospitalizations and high mortality.

KW - HIV/AIDS

KW - immunocompromise

KW - mortality

KW - mpox treatment

KW - tecovirimat

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DO - 10.1093/ofid/ofae294

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JO - Open Forum Infectious Diseases

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IS - 6

M1 - ofae294

ER -

Severe Mpox Among People With Advanced Human Immunodeficiency Virus Receiving Prolonged Tecovirimat in New York City

Abstract

Keywords

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