Severe cholestasis–associated coagulopathy diagnosed by routine screening: a case report

Minhazur R. Sarker; Leslie Warren; Chloe Getrajdman; Lauren Ferrara

doi:10.1016/j.xagr.2023.100235

Severe cholestasis–associated coagulopathy diagnosed by routine screening: a case report

Minhazur R. Sarker, Leslie Warren, Chloe Getrajdman, Lauren Ferrara

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Recent case reports suggest an association between severe intrahepatic cholestasis of pregnancy and fat-soluble vitamin deficiencies, including vitamin K deficiency. Screening for coagulopathy and fat-soluble vitamin deficiency has been proposed as a possible strategy to identify pregnancies at additional risk of adverse outcomes and allow for earlier risk-reducing iatrogenic preterm delivery. This report highlights a case of routine screening that resulted in the detection of subclinical coagulopathy that allowed for earlier intervention and delivery of a healthy neonate at 34 weeks of gestation. Further prospective studies are needed to determine the clinical use of routine screening in detecting coagulopathy and fat-soluble vitamin deficiency in cases of severe cholestasis.

Original language	English
Article number	100235
Journal	AJOG Global Reports
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/j.xagr.2023.100235
State	Published - Aug 2023

Keywords

bile acids
case report
cholestasis
fat-soluble vitamins
liver transplant
vitamin K

Access to Document

10.1016/j.xagr.2023.100235

Cite this

@article{ced82f4eb693422eaa991898abee5d82,

title = "Severe cholestasis–associated coagulopathy diagnosed by routine screening: a case report",

abstract = "Recent case reports suggest an association between severe intrahepatic cholestasis of pregnancy and fat-soluble vitamin deficiencies, including vitamin K deficiency. Screening for coagulopathy and fat-soluble vitamin deficiency has been proposed as a possible strategy to identify pregnancies at additional risk of adverse outcomes and allow for earlier risk-reducing iatrogenic preterm delivery. This report highlights a case of routine screening that resulted in the detection of subclinical coagulopathy that allowed for earlier intervention and delivery of a healthy neonate at 34 weeks of gestation. Further prospective studies are needed to determine the clinical use of routine screening in detecting coagulopathy and fat-soluble vitamin deficiency in cases of severe cholestasis.",

keywords = "bile acids, case report, cholestasis, fat-soluble vitamins, liver transplant, vitamin K",

author = "Sarker, {Minhazur R.} and Leslie Warren and Chloe Getrajdman and Lauren Ferrara",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = aug,

doi = "10.1016/j.xagr.2023.100235",

language = "English",

volume = "3",

journal = "AJOG Global Reports",

issn = "2666-5778",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Severe cholestasis–associated coagulopathy diagnosed by routine screening

T2 - a case report

AU - Sarker, Minhazur R.

AU - Warren, Leslie

AU - Getrajdman, Chloe

AU - Ferrara, Lauren

PY - 2023/8

Y1 - 2023/8

N2 - Recent case reports suggest an association between severe intrahepatic cholestasis of pregnancy and fat-soluble vitamin deficiencies, including vitamin K deficiency. Screening for coagulopathy and fat-soluble vitamin deficiency has been proposed as a possible strategy to identify pregnancies at additional risk of adverse outcomes and allow for earlier risk-reducing iatrogenic preterm delivery. This report highlights a case of routine screening that resulted in the detection of subclinical coagulopathy that allowed for earlier intervention and delivery of a healthy neonate at 34 weeks of gestation. Further prospective studies are needed to determine the clinical use of routine screening in detecting coagulopathy and fat-soluble vitamin deficiency in cases of severe cholestasis.

AB - Recent case reports suggest an association between severe intrahepatic cholestasis of pregnancy and fat-soluble vitamin deficiencies, including vitamin K deficiency. Screening for coagulopathy and fat-soluble vitamin deficiency has been proposed as a possible strategy to identify pregnancies at additional risk of adverse outcomes and allow for earlier risk-reducing iatrogenic preterm delivery. This report highlights a case of routine screening that resulted in the detection of subclinical coagulopathy that allowed for earlier intervention and delivery of a healthy neonate at 34 weeks of gestation. Further prospective studies are needed to determine the clinical use of routine screening in detecting coagulopathy and fat-soluble vitamin deficiency in cases of severe cholestasis.

KW - bile acids

KW - case report

KW - cholestasis

KW - fat-soluble vitamins

KW - liver transplant

KW - vitamin K

UR - http://www.scopus.com/inward/record.url?scp=85161926652&partnerID=8YFLogxK

U2 - 10.1016/j.xagr.2023.100235

DO - 10.1016/j.xagr.2023.100235

M3 - Article

AN - SCOPUS:85161926652

SN - 2666-5778

VL - 3

JO - AJOG Global Reports

JF - AJOG Global Reports

IS - 3

M1 - 100235

ER -

Severe cholestasis–associated coagulopathy diagnosed by routine screening: a case report

Abstract

Keywords

Access to Document

Fingerprint

Cite this