Severe cholestasis–associated coagulopathy diagnosed by routine screening: a case report

Minhazur R. Sarker, Leslie Warren, Chloe Getrajdman, Lauren Ferrara

Research output: Contribution to journalArticlepeer-review

Abstract

Recent case reports suggest an association between severe intrahepatic cholestasis of pregnancy and fat-soluble vitamin deficiencies, including vitamin K deficiency. Screening for coagulopathy and fat-soluble vitamin deficiency has been proposed as a possible strategy to identify pregnancies at additional risk of adverse outcomes and allow for earlier risk-reducing iatrogenic preterm delivery. This report highlights a case of routine screening that resulted in the detection of subclinical coagulopathy that allowed for earlier intervention and delivery of a healthy neonate at 34 weeks of gestation. Further prospective studies are needed to determine the clinical use of routine screening in detecting coagulopathy and fat-soluble vitamin deficiency in cases of severe cholestasis.

Original languageEnglish
Article number100235
JournalAJOG Global Reports
Volume3
Issue number3
DOIs
StatePublished - Aug 2023

Keywords

  • bile acids
  • case report
  • cholestasis
  • fat-soluble vitamins
  • liver transplant
  • vitamin K

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