Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors

Nancy Habib, Cristina Salaro, Khalid Al-Ghaithi, Robert G. Phelps, Sarika Saggar, Steven R. Cohen

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy. This association has been reported less frequently with tacrolimus. Case: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus. Conclusion: Since these drugs are used widely in the pediatric transplantation population, this report serves to heighten awareness of this debilitating phenomenon, and to stress the importance of exercising caution when sirolimus and tacrolimus are administered in combination to pediatric patients.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalInternational Journal of Dermatology
Issue number1
StatePublished - Jan 2010


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