Serum-Thyreoglobulinspiegel als Tumormarker bei Schilddrüsencarcinom

Translated title of the contribution: Significance of thyroglobulin as a tumor marker in the serum of patients with differentiated thyroid carcinoma: Longitudinal and cross-sectional studies

H. Schatz, S. Grebe, E. Mäser, J. Teuber, W. Horn, O. Schröder, Ch Schatz

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

For evaluating the clinical significance of thyroglobulin measurements for the follow-up of patients with differentiated thyroid carcinoma, thyroglobulin was determined radioimmunologically during the past 2 years (up to 12 times) in 40 patients after withdrawal of thyroid hormone. Thyroglobulin values were compared with whole-body scintigrams after radioiodine. Thyroglobulin antibodies, which may interfere in the radioimmunoassay for thyroglobulin, were also estimated by a radioimmunologic method. In the majority of cases, thyroglobulin levels corresponded to the scintigrams, however, the thyroglobulin level appeared to be a more precise index for changes in tumor tissue mass. In one patient the scintigram was negative, whereas considerable amounts of thyroglobulin were measured in the serum: X-ray tomography ravealed a lung metastase in this case. On the other hand, thyroglobulin was undetectable in the sera of patients who exhibited distinct metastases in the scintigram. Thyroglobulin can be regarded as a tumor marker in patients thyroidectomized for differentiated thyroid carcinoma. However, its determination can certainly not replace whole-body scintigraphy as postulated by several authors, although thyroglobulin measurement appears to be superior to scanning in some cases. A combined application of iodine scanning and thyroglobulin radioimmunoassay is thus advisable in the follow-up of patients with differentiated thyroid carcinoma.

Translated title of the contributionSignificance of thyroglobulin as a tumor marker in the serum of patients with differentiated thyroid carcinoma: Longitudinal and cross-sectional studies
Original languageGerman
Pages (from-to)457-464
Number of pages8
JournalKlinische Wochenschrift
Volume60
Issue number9
DOIs
StatePublished - May 1982
Externally publishedYes

Keywords

  • Metastases
  • Radioiodine therapy
  • Thyroglobulin
  • Thyroglobulin antibodies
  • Thyroid carcinoma

Fingerprint

Dive into the research topics of 'Significance of thyroglobulin as a tumor marker in the serum of patients with differentiated thyroid carcinoma: Longitudinal and cross-sectional studies'. Together they form a unique fingerprint.

Cite this