Serum protein marker panel for predicting preeclampsia

Lifeng Cui, Chang Shu, Zitao Liu, Weihua Tong, Miao Cui, Chengguo Wei, Jian Jenny Tang, Xiufen Liu, Hujing Hai, Jing Jiang, Jin He, David Y. Zhang, Fei Ye, Yulin Li

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Background: Preeclampsia is a multi-system disorder in pregnancy which has no effective treatment. The diagnosis of preeclampsia is based on clinical presentation and routine laboratory tests. Objective: This study aimed at identifying serum protein markers for diagnosis of preeclampsia and predicting its severe features. Study design: In total, 172 pregnant women were enrolled in this study including 110 subjects with preeclampsia and 62 normotensive subjects. Eleven serum proteins (VEGF, sFlt-1, sEndoglin, PlGF, sEGFR, prolactin, PTX3, PAI-1, NGAL, IL-27, COX-2) were assessed using Luminex multiplex immunoassay and ELISA. Results: The levels of seven proteins (sFlt-1, VEGF, sEndoglin, sEGFR, PlGF, NGAL, COX-2) correlated with preeclampsia, and 4 proteins (VEGF, sEndoglin, PlGF, sEGFR) were identified as independent factors associated with preeclampsia. The levels of three proteins (sEndoglin, PTX3, sFlt-1) correlated with severe features of preeclampsia, and three variables (serum creatinine, platelet count and sEndoglin) were identified as independent factors in predicting severe features of preeclampsia. Conclusions: A combination of serum protein markers (VEGF, sEndoglin, PlGF, sEGFR) and clinical variables (serum creatinine, platelet count and sEndoglin) could be used as analytical tool in diagnosis of preeclampsia and its severe features, respectively. Serum sEGFR, a novel biomarker in preeclampsia, may be involved in the pathogenesis of preeclampsia.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalPregnancy Hypertension
Volume14
DOIs
StatePublished - Oct 2018

Keywords

  • Diagnostic biomarkers
  • Diagnostics of preeclampsia
  • Preeclampsia
  • Pregnancy
  • Severe features of preeclampsia

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