Serum leptin level in women with idiopathic intracranial hypertension

Y. Lampl; Y. Eshel; A. Kessler; A. Fux; R. Gilad; M. Boaz; Z. Matas; M. Sadeh

doi:10.1136/jnnp.72.5.642

Serum leptin level in women with idiopathic intracranial hypertension

Y. Lampl, Y. Eshel, A. Kessler, A. Fux, R. Gilad, M. Boaz, Z. Matas, M. Sadeh

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Leptin is a protein secreted by adipose cells which influences regulation of energy balance and body weight. Idiopathic intracranial hypertension (IIH) is recognised as a neurological disorder mainly affecting obese females. The aim of this study was to evaluate the association between IIH and serum leptin level in 15 obese patients and compare the results with those for 16 obese and 15 non-obese women. A significantly higher serum leptin level was found in patients with IIH than in controls (p<0.0001), and this did not correlate with body mass index (BMI). Serum leptin levels were significantly associated with BMI in both control groups (p<0.0006). Additional factors must therefore be involved in the phenomenon of serum leptin increase beyond weight gain. The cause can only be hypothesised, but it seems that the origin is central, probably hypothalamic.

Original language	English
Pages (from-to)	642-643
Number of pages	2
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	72
Issue number	5
DOIs	https://doi.org/10.1136/jnnp.72.5.642
State	Published - 2002
Externally published	Yes

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title = "Serum leptin level in women with idiopathic intracranial hypertension",

abstract = "Leptin is a protein secreted by adipose cells which influences regulation of energy balance and body weight. Idiopathic intracranial hypertension (IIH) is recognised as a neurological disorder mainly affecting obese females. The aim of this study was to evaluate the association between IIH and serum leptin level in 15 obese patients and compare the results with those for 16 obese and 15 non-obese women. A significantly higher serum leptin level was found in patients with IIH than in controls (p<0.0001), and this did not correlate with body mass index (BMI). Serum leptin levels were significantly associated with BMI in both control groups (p<0.0006). Additional factors must therefore be involved in the phenomenon of serum leptin increase beyond weight gain. The cause can only be hypothesised, but it seems that the origin is central, probably hypothalamic.",

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T1 - Serum leptin level in women with idiopathic intracranial hypertension

AU - Lampl, Y.

AU - Eshel, Y.

AU - Kessler, A.

AU - Fux, A.

AU - Gilad, R.

AU - Boaz, M.

AU - Matas, Z.

AU - Sadeh, M.

PY - 2002

Y1 - 2002

N2 - Leptin is a protein secreted by adipose cells which influences regulation of energy balance and body weight. Idiopathic intracranial hypertension (IIH) is recognised as a neurological disorder mainly affecting obese females. The aim of this study was to evaluate the association between IIH and serum leptin level in 15 obese patients and compare the results with those for 16 obese and 15 non-obese women. A significantly higher serum leptin level was found in patients with IIH than in controls (p<0.0001), and this did not correlate with body mass index (BMI). Serum leptin levels were significantly associated with BMI in both control groups (p<0.0006). Additional factors must therefore be involved in the phenomenon of serum leptin increase beyond weight gain. The cause can only be hypothesised, but it seems that the origin is central, probably hypothalamic.

AB - Leptin is a protein secreted by adipose cells which influences regulation of energy balance and body weight. Idiopathic intracranial hypertension (IIH) is recognised as a neurological disorder mainly affecting obese females. The aim of this study was to evaluate the association between IIH and serum leptin level in 15 obese patients and compare the results with those for 16 obese and 15 non-obese women. A significantly higher serum leptin level was found in patients with IIH than in controls (p<0.0001), and this did not correlate with body mass index (BMI). Serum leptin levels were significantly associated with BMI in both control groups (p<0.0006). Additional factors must therefore be involved in the phenomenon of serum leptin increase beyond weight gain. The cause can only be hypothesised, but it seems that the origin is central, probably hypothalamic.

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Serum leptin level in women with idiopathic intracranial hypertension

Abstract

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