Serum Interferon Inhibitor Declines in Patients with HIV-1 Infection After a Change in Antiretroviral Therapy

Kailash C. Chadha, Stanley A. Schwartz, Madhavan P.N. Nair, Lisa R. Demeter, Ross G. Hewitt

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

An inhibitor of interferon antiviral activity, which is absent in healthy HIV-seronegative persons, was detected in the sera of all 29 HIV-seropositive study participants. The relationship of the level of interferon inhibitor to CD4 count and HIV-RNA copy number was statistically significant in distinct models. Levels of interferon inhibitor declined by an average of 41-60% in patients who underwent a change in anti-retroviral therapy. Interferon inhibitor levels appear to decline as CD4 cell count rises and HIV-RNA levels fall. This suggests that interferon inhibitor may have a significant role in the host immune response to HIV infection.

Original languageEnglish
Pages (from-to)299-312
Number of pages14
JournalImmunological Investigations
Volume32
Issue number4
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Antiretroviral therapy
  • HIV-RNA levels
  • HIV-infection
  • Serum interferon inhibitor
  • Serum interferon levels

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