Serum elastase inhibitor deficiency and α1-antitrypsin deficiency in patients with obstructive emphysema

Gerard M. Turino; Robert M. Senior; Bhagwan D. Garg; Steven Keller; Michael M. Levi; Ines Mandl

doi:10.1126/science.165.3894.709

Serum elastase inhibitor deficiency and α₁-antitrypsin deficiency in patients with obstructive emphysema

Gerard M. Turino
, Robert M. Senior
, Bhagwan D. Garg
, Steven Keller
, Michael M. Levi
, Ines Mandl

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

A decreased inhibition of pancreatic elastase has been detected in the serums of six patients with α₁-antitrypsin deficiency. Five have severe clinical and physiological pulmonary emphysema. This observation extends the defect of inhibition by serum to a second, biologically active proteolytic enzyme in this form of familial emphysema.

Original language	English
Pages (from-to)	709-711
Number of pages	3
Journal	Science
Volume	165
Issue number	3894
DOIs	https://doi.org/10.1126/science.165.3894.709
State	Published - 1969
Externally published	Yes

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10.1126/science.165.3894.709

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title = "Serum elastase inhibitor deficiency and α1-antitrypsin deficiency in patients with obstructive emphysema",

abstract = "A decreased inhibition of pancreatic elastase has been detected in the serums of six patients with α1-antitrypsin deficiency. Five have severe clinical and physiological pulmonary emphysema. This observation extends the defect of inhibition by serum to a second, biologically active proteolytic enzyme in this form of familial emphysema.",

author = "Turino, \{Gerard M.\} and Senior, \{Robert M.\} and Garg, \{Bhagwan D.\} and Steven Keller and Levi, \{Michael M.\} and Ines Mandl",

year = "1969",

doi = "10.1126/science.165.3894.709",

language = "English",

volume = "165",

pages = "709--711",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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TY - JOUR

T1 - Serum elastase inhibitor deficiency and α1-antitrypsin deficiency in patients with obstructive emphysema

AU - Turino, Gerard M.

AU - Senior, Robert M.

AU - Garg, Bhagwan D.

AU - Keller, Steven

AU - Levi, Michael M.

AU - Mandl, Ines

PY - 1969

Y1 - 1969

N2 - A decreased inhibition of pancreatic elastase has been detected in the serums of six patients with α1-antitrypsin deficiency. Five have severe clinical and physiological pulmonary emphysema. This observation extends the defect of inhibition by serum to a second, biologically active proteolytic enzyme in this form of familial emphysema.

AB - A decreased inhibition of pancreatic elastase has been detected in the serums of six patients with α1-antitrypsin deficiency. Five have severe clinical and physiological pulmonary emphysema. This observation extends the defect of inhibition by serum to a second, biologically active proteolytic enzyme in this form of familial emphysema.

UR - https://www.scopus.com/pages/publications/0014678424

U2 - 10.1126/science.165.3894.709

DO - 10.1126/science.165.3894.709

M3 - Article

C2 - 5793975

AN - SCOPUS:0014678424

SN - 0036-8075

VL - 165

SP - 709

EP - 711

JO - Science

JF - Science

IS - 3894

ER -

Serum elastase inhibitor deficiency and α1-antitrypsin deficiency in patients with obstructive emphysema

Abstract

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Serum elastase inhibitor deficiency and α₁-antitrypsin deficiency in patients with obstructive emphysema