Serum elastase inhibitor deficiency and α1-antitrypsin deficiency in patients with obstructive emphysema

Gerard M. Turino, Robert M. Senior, Bhagwan D. Garg, Steven Keller, Michael M. Levi, Ines Mandl

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

A decreased inhibition of pancreatic elastase has been detected in the serums of six patients with α1-antitrypsin deficiency. Five have severe clinical and physiological pulmonary emphysema. This observation extends the defect of inhibition by serum to a second, biologically active proteolytic enzyme in this form of familial emphysema.

Original languageEnglish
Pages (from-to)709-711
Number of pages3
JournalScience
Volume165
Issue number3894
DOIs
StatePublished - 1969
Externally publishedYes

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