@article{4a8b03cdc7e34f628b98b088c730db59,
title = "Serotonin levels and 1-year mortality in patients with neuroendocrine tumors: A systematic review and meta-analysis",
abstract = " Aim: Elevated serotonin in patients with neuroendocrine tumors (NETs) may impact heart failure incidence but a quantitative relationship has not been established. Materials & methods: Systematic review and meta-analysis of studies assessing 24-h urinary 5-hydroxyindoleacetic acid (u5-HIAA) and mortality in patients with NETs (2007-2017) with a primary outcome of 1-year mortality risk and 24-h u5-HIAA. Results: We identified 1715 records of which 12 studies including 755 patients (3442 person-years with 376 deaths) were eligible for meta-analysis. Mean u5-HIAA was 149.2 mg/24 h (standard deviation: 96.6) and mortality was 13.0%. The meta-regression equation showed an 11.8% (95% CI: 8.9-17.0%; I 2 = 93.0%) increase in 1-year mortality for every ten-unit increase in u5-HIAA. Conclusion: Serotonin measured by its metabolite u5-HIAA is predictive of 1-year all-cause mortality in patients with NETs.",
keywords = "carcinoid syndrome, mortality, neuroendocrine tumors, serotonin",
author = "Joish, {Vijay N.} and Sandip Shah and Tierce, {Jonothan C.} and Deep Patel and Chad McKee and Pablo Lapuerta and Jerome Zacks",
note = "Funding Information: This work was funded by Lexicon Pharmaceuticals, Inc. J Zacks reports personal fees (research funding and consulting fees) from Lexicon Pharmaceuticals, Inc. VN Joish and P Lapuerta report personal fees (employment and stock ownership) from Lexicon Pharmaceuticals, Inc. S Shah, JC Tierce and D Patel report personal fees (research consulting fees) from Lexicon Pharmaceuticals, Inc. C McKee reports personal fees (employment at the time of the study) from Lexicon Pharmaceuticals, Inc. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2019 2019 Vijay N Joish.",
year = "2019",
month = apr,
doi = "10.2217/fon-2018-0960",
language = "English",
volume = "15",
pages = "1397--1406",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "12",
}