Serotonin function and panic disorder

R. S. Kahn

doi:10.1016/0924-977X(93)90058-T

Serotonin function and panic disorder

R. S. Kahn

Research output: Contribution to journal › Article › peer-review

Abstract

Increasing serotonin (5-hydroxytryptamine 5HT) function is anxiogenic in animals and man. Patients with panic disorder appear hypersensitive to the anxiogenic effect of increasing 5HT function, possibly due to increased sensitivity of postsynaptic 5HT1c or 5HT3 receptors. Presynaptic (5HT1a) function may be reduced in panic disorder patients. Both phenomena can be explained as the result of decreased production of 5HT in the presynaptic neuron.

Original language	English
Pages (from-to)	256-257
Number of pages	2
Journal	European Neuropsychopharmacology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/0924-977X(93)90058-T
State	Published - Sep 1993
Externally published	Yes

Keywords

Anxiety
Panic disorder
Serotonin

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10.1016/0924-977X(93)90058-T

Cite this

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title = "Serotonin function and panic disorder",

abstract = "Increasing serotonin (5-hydroxytryptamine 5HT) function is anxiogenic in animals and man. Patients with panic disorder appear hypersensitive to the anxiogenic effect of increasing 5HT function, possibly due to increased sensitivity of postsynaptic 5HT1c or 5HT3 receptors. Presynaptic (5HT1a) function may be reduced in panic disorder patients. Both phenomena can be explained as the result of decreased production of 5HT in the presynaptic neuron.",

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AU - Kahn, R. S.

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AB - Increasing serotonin (5-hydroxytryptamine 5HT) function is anxiogenic in animals and man. Patients with panic disorder appear hypersensitive to the anxiogenic effect of increasing 5HT function, possibly due to increased sensitivity of postsynaptic 5HT1c or 5HT3 receptors. Presynaptic (5HT1a) function may be reduced in panic disorder patients. Both phenomena can be explained as the result of decreased production of 5HT in the presynaptic neuron.

KW - Anxiety

KW - Panic disorder

KW - Serotonin

UR - https://www.scopus.com/pages/publications/0027818868

U2 - 10.1016/0924-977X(93)90058-T

DO - 10.1016/0924-977X(93)90058-T

M3 - Article

AN - SCOPUS:0027818868

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VL - 3

SP - 256

EP - 257

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 3

ER -

Serotonin function and panic disorder

Abstract

Keywords

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