Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate

William P. Clarke; Michael De Vivo; Sheryl G. Beck; Saul Maayani; Joseph Goldfarb

doi:10.1016/0006-8993(87)90338-6

Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate

William P. Clarke
, Michael De Vivo
, Sheryl G. Beck
, Saul Maayani
, Joseph Goldfarb

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Activation of the serotonin_1A receptor decreases CA₁ population spike amplitude and inhibits forskolin-stimulated adenylate cyclase in rat hippocampus. Pretreatment of rats with pertussis toxin blocked both responses. Because the electrophysiological and biochemical responses to serotonin were correlated after pertussis toxin treatment, we conclude that both responses are mediated by a common regulatory protein, presumably G_i.

Original language	English
Pages (from-to)	357-361
Number of pages	5
Journal	Brain Research
Volume	410
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(87)90338-6
State	Published - 5 May 1987
Externally published	Yes

Keywords

Adenylate cyclase
G protein
Hippocampus
Pertussis toxin
Population spike
Serotonin

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10.1016/0006-8993(87)90338-6

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@article{cb71ed4cf33a467799da9627267e68c6,

title = "Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate",

abstract = "Activation of the serotonin1A receptor decreases CA1 population spike amplitude and inhibits forskolin-stimulated adenylate cyclase in rat hippocampus. Pretreatment of rats with pertussis toxin blocked both responses. Because the electrophysiological and biochemical responses to serotonin were correlated after pertussis toxin treatment, we conclude that both responses are mediated by a common regulatory protein, presumably Gi.",

keywords = "Adenylate cyclase, G protein, Hippocampus, Pertussis toxin, Population spike, Serotonin",

author = "Clarke, \{William P.\} and \{De Vivo\}, Michael and Beck, \{Sheryl G.\} and Saul Maayani and Joseph Goldfarb",

note = "Funding Information: This work was supported by NIH postdoctoral Training Grant DA-07135. a Pharmaceutical Manufacturers Association Foundation fellowship to M.D.V., and Grants DA-01875 from the National Institute on Drug Abuse. GM-34852 from the National Institute of General Medical Sciences. and MH-41917 from the National Institute of Mental Health. Data analyses were performed on the PROPHET Computer System, a national resource supported by the Biochemical Research Technology Program. Division of Research Resources. National Institutes of Health.",

year = "1987",

month = may,

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doi = "10.1016/0006-8993(87)90338-6",

language = "English",

volume = "410",

pages = "357--361",

journal = "Brain Research",

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number = "2",

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T1 - Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate

AU - Clarke, William P.

AU - De Vivo, Michael

AU - Beck, Sheryl G.

AU - Maayani, Saul

AU - Goldfarb, Joseph

N1 - Funding Information: This work was supported by NIH postdoctoral Training Grant DA-07135. a Pharmaceutical Manufacturers Association Foundation fellowship to M.D.V., and Grants DA-01875 from the National Institute on Drug Abuse. GM-34852 from the National Institute of General Medical Sciences. and MH-41917 from the National Institute of Mental Health. Data analyses were performed on the PROPHET Computer System, a national resource supported by the Biochemical Research Technology Program. Division of Research Resources. National Institutes of Health.

PY - 1987/5/5

Y1 - 1987/5/5

N2 - Activation of the serotonin1A receptor decreases CA1 population spike amplitude and inhibits forskolin-stimulated adenylate cyclase in rat hippocampus. Pretreatment of rats with pertussis toxin blocked both responses. Because the electrophysiological and biochemical responses to serotonin were correlated after pertussis toxin treatment, we conclude that both responses are mediated by a common regulatory protein, presumably Gi.

AB - Activation of the serotonin1A receptor decreases CA1 population spike amplitude and inhibits forskolin-stimulated adenylate cyclase in rat hippocampus. Pretreatment of rats with pertussis toxin blocked both responses. Because the electrophysiological and biochemical responses to serotonin were correlated after pertussis toxin treatment, we conclude that both responses are mediated by a common regulatory protein, presumably Gi.

KW - Adenylate cyclase

KW - G protein

KW - Hippocampus

KW - Pertussis toxin

KW - Population spike

KW - Serotonin

UR - https://www.scopus.com/pages/publications/0023267409

U2 - 10.1016/0006-8993(87)90338-6

DO - 10.1016/0006-8993(87)90338-6

M3 - Article

C2 - 3594245

AN - SCOPUS:0023267409

SN - 0006-8993

VL - 410

SP - 357

EP - 361

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate

Abstract

Keywords

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