TY - JOUR
T1 - Serotonergic sensitivity in borderline personality disorder
T2 - Preliminary findings
AU - Hollander, Eric
AU - Stein, Dan J.
AU - DeCaria, Concetta M.
AU - Cohen, Lisa
AU - Saoud, Jihad B.
AU - Skodol, Andrew E.
AU - Kellman, David
AU - Rosnick, Lyle
AU - Oldham, John M.
PY - 1994/2
Y1 - 1994/2
N2 - Twelve patients with borderline personality disorder and 15 healthy comparison subjects were challenged with single doses of oral m- chlorophenylpiperazine (m-CPP) and placebo. Following m-CPP, the patients experienced decreased anger and fear. Seven of the 12 patients reported a 'spacy,' 'high,' depersonalized/derealized experience following m-CPP, which was confirmed by clinicians' ratings. Compared with the normal male subjects, the male patients with borderline personality disorder had higher cortisol levels and marginally blunted prolactin responses after receiving m-CPP. These results suggest serotonergic dysfunction in borderline personality disorder.
AB - Twelve patients with borderline personality disorder and 15 healthy comparison subjects were challenged with single doses of oral m- chlorophenylpiperazine (m-CPP) and placebo. Following m-CPP, the patients experienced decreased anger and fear. Seven of the 12 patients reported a 'spacy,' 'high,' depersonalized/derealized experience following m-CPP, which was confirmed by clinicians' ratings. Compared with the normal male subjects, the male patients with borderline personality disorder had higher cortisol levels and marginally blunted prolactin responses after receiving m-CPP. These results suggest serotonergic dysfunction in borderline personality disorder.
UR - http://www.scopus.com/inward/record.url?scp=0028107319&partnerID=8YFLogxK
U2 - 10.1176/ajp.151.2.277
DO - 10.1176/ajp.151.2.277
M3 - Article
C2 - 8296905
AN - SCOPUS:0028107319
SN - 0002-953X
VL - 151
SP - 277
EP - 280
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 2
ER -