TY - JOUR
T1 - Serotonergic Function in Obsessive-Compulsive Disorder
T2 - Behavioral and Neuroendocrine Responses to Oral m-Chlorophenylpiperazine and Fenfluramine in Patients and Healthy Volunteers
AU - Hollander, Eric
AU - Decaria, Concetta M.
AU - Nitescu, Anca
AU - Gully, Robert
AU - Suckow, Raymond F.
AU - Cooper, Thomas B.
AU - Gorman, Jack M.
AU - Klein, Donald F.
AU - Liebowitz, Michael R.
N1 - Funding Information:
ThisinvestigationwassupportedinpartbygrantsMH-30906New YorkStatePsychiatricInstituteMentalHealthClinicalResearch Center,BiomedicaiResearch Support Grants, and Research Scientist DevelopmentAwardMH-00750(DrHollander)fromtheNational InstituteofMentalHealth,Bethesda,Md. DonaldRoss, PhD, andJihadB. Saoud, MS, provided statistical consultation;MichaelFay,RN,providedearlyassistance;Hanna Novacenko,MS,andD.Allenprovidedbiochemicalandneuroen¬ docrineassays;andEmilCoccaro,MD,reviewedthemanuscript. TheNationalPituitaryAgencyprovidedtheprolactinantibodyand standard,andthepharmacyattheNewYorkStatePsychiatricInsti¬ tute,NewYork,gaveassistance. ApreliminarydraftofthisarticlereceivedtheAmericanPsychi¬ atricAssociation/WisniewskiYoungPsychiatristResearchAwardat the143rdAnnualMeetingoftheAmericanPsychiatricAssociation, May (DrHollander).
PY - 1992/1
Y1 - 1992/1
N2 - • To evaluate serotonergic (5-hydroxytryptamine) function in obsessive-compulsive disorder, behavioral and neuroendocrine responses to m-chlorophenylpiperazine (m-CPP; 0.5 mg/kg orally) and fenfluramine hydrochloride (60 mg orally) were examined in 20 patients and 10 healthy controls under double-blind, placebo-controlled conditions. Following m-CPP, but not fenfluramine or placebo, 55% (11/20) of the patients with obsessive-compulsive disorder experienced a transient exacerbation of obsessivecompulsive disorder. Prolactin response was blunted in patients following m-CPP but not following fenfluramine. Patients with greater behavioral response to m-CPP had smaller prolactin responses. Cortisol response to m-CPP and fenfluramine did not significantly differ between the groups. Behavioral and neuroendocrine responses appeared divergent. This does not suggest simply upregulation or downregulation of 5-hydroxytryptamine receptors, but rather complex mechanisms involving multiple neurotransmitter and neuromodulator systems.
AB - • To evaluate serotonergic (5-hydroxytryptamine) function in obsessive-compulsive disorder, behavioral and neuroendocrine responses to m-chlorophenylpiperazine (m-CPP; 0.5 mg/kg orally) and fenfluramine hydrochloride (60 mg orally) were examined in 20 patients and 10 healthy controls under double-blind, placebo-controlled conditions. Following m-CPP, but not fenfluramine or placebo, 55% (11/20) of the patients with obsessive-compulsive disorder experienced a transient exacerbation of obsessivecompulsive disorder. Prolactin response was blunted in patients following m-CPP but not following fenfluramine. Patients with greater behavioral response to m-CPP had smaller prolactin responses. Cortisol response to m-CPP and fenfluramine did not significantly differ between the groups. Behavioral and neuroendocrine responses appeared divergent. This does not suggest simply upregulation or downregulation of 5-hydroxytryptamine receptors, but rather complex mechanisms involving multiple neurotransmitter and neuromodulator systems.
UR - https://www.scopus.com/pages/publications/0026519130
U2 - 10.1001/archpsyc.1992.01820010021003
DO - 10.1001/archpsyc.1992.01820010021003
M3 - Article
C2 - 1728249
AN - SCOPUS:0026519130
SN - 0003-990X
VL - 49
SP - 21
EP - 28
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 1
ER -