Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder

Jeffrey M. Halperin; Vanshdeep Sharma; Larry J. Siever; Susan T. Schwartz; Kristin Matier; Gibsi Wornell; Jeffrey H. Newcorn

doi:10.1176/ajp.151.2.243

Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder

Jeffrey M. Halperin, Vanshdeep Sharma, Larry J. Siever, Susan T. Schwartz, Kristin Matier, Gibsi Wornell, Jeffrey H. Newcorn

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

Objective: This study was designed to assess central serotonergic (5-HT) function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. Method: Prolactin response to a challenge dose of the 5-HT agonist d,l-fenfluramine was assessed in 25 7-11-year-old boys with attention deficit hyperactivity disorder who were divided into aggressive and nonaggressive subgroups. In addition, the subgroups were compared on plasma catecholamine metabolites and platelet 5-HT. Results: The aggressive group had a significantly greater prolactin response to the fenfluramine challenge than the nonaggressive subgroup. The groups did not differ on peripheral measures of neurotransmitter function. Conclusions: These data suggest that aggressive and nonaggressive children with attention deficit hyperactivity disorder differ in central 5-HT functioning.

Original language	English
Pages (from-to)	243-248
Number of pages	6
Journal	American Journal of Psychiatry
Volume	151
Issue number	2
DOIs	https://doi.org/10.1176/ajp.151.2.243
State	Published - Feb 1994

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title = "Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder",

abstract = "Objective: This study was designed to assess central serotonergic (5-HT) function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. Method: Prolactin response to a challenge dose of the 5-HT agonist d,l-fenfluramine was assessed in 25 7-11-year-old boys with attention deficit hyperactivity disorder who were divided into aggressive and nonaggressive subgroups. In addition, the subgroups were compared on plasma catecholamine metabolites and platelet 5-HT. Results: The aggressive group had a significantly greater prolactin response to the fenfluramine challenge than the nonaggressive subgroup. The groups did not differ on peripheral measures of neurotransmitter function. Conclusions: These data suggest that aggressive and nonaggressive children with attention deficit hyperactivity disorder differ in central 5-HT functioning.",

author = "Halperin, {Jeffrey M.} and Vanshdeep Sharma and Siever, {Larry J.} and Schwartz, {Susan T.} and Kristin Matier and Gibsi Wornell and Newcorn, {Jeffrey H.}",

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AU - Halperin, Jeffrey M.

AU - Sharma, Vanshdeep

AU - Siever, Larry J.

AU - Schwartz, Susan T.

AU - Matier, Kristin

AU - Wornell, Gibsi

AU - Newcorn, Jeffrey H.

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Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder

Abstract

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