TY - JOUR
T1 - Seroprevalence of Lyme Disease in Children With Facial Nerve Palsy
AU - Murphy, Bethany
AU - Veras, Julissa
AU - Kolli, Sindhura
AU - Formanowski, Brielle
AU - Greenberg, Patricia
AU - Kleinman, Lawrence
AU - Malhotra, Amisha
AU - Bhise, Vikram
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - This retrospective chart review examined children with documented Lyme disease serology in New Jersey aged <21 years presenting with facial nerve palsy. The presence of symptoms including tick bite, fever, headache, and arthritis was recorded. Data were categorized based on demographic factors, and multivariate regression was employed. We enrolled 122 children, 54% female (mean age of 11.4 ± 5.1 years); 22.1% had Lyme disease. Fever was a significant predictor of Lyme disease (P =.01), confirmed by multivariate regression (odds ratio [OR] = 16.11, 95% confidence interval [CI] = 2.04, 366.14), as was male gender (P =.01, OR = 3.68, 95% CI = 1.21, 12.89). This association held especially true in Lyme-endemic regions (prevalence ≥ 0.35). The combination of headache with fever was also significantly predictive (P =.01). We found no significant predictive value in the remaining symptoms. These findings suggest that clinical predictors may be useful in diagnosing Lyme disease and initiating early empiric treatment.
AB - This retrospective chart review examined children with documented Lyme disease serology in New Jersey aged <21 years presenting with facial nerve palsy. The presence of symptoms including tick bite, fever, headache, and arthritis was recorded. Data were categorized based on demographic factors, and multivariate regression was employed. We enrolled 122 children, 54% female (mean age of 11.4 ± 5.1 years); 22.1% had Lyme disease. Fever was a significant predictor of Lyme disease (P =.01), confirmed by multivariate regression (odds ratio [OR] = 16.11, 95% confidence interval [CI] = 2.04, 366.14), as was male gender (P =.01, OR = 3.68, 95% CI = 1.21, 12.89). This association held especially true in Lyme-endemic regions (prevalence ≥ 0.35). The combination of headache with fever was also significantly predictive (P =.01). We found no significant predictive value in the remaining symptoms. These findings suggest that clinical predictors may be useful in diagnosing Lyme disease and initiating early empiric treatment.
KW - children
KW - epidemiology
KW - meningitis
KW - pediatric
UR - http://www.scopus.com/inward/record.url?scp=85202872777&partnerID=8YFLogxK
U2 - 10.1177/08830738241272069
DO - 10.1177/08830738241272069
M3 - Article
C2 - 39196299
AN - SCOPUS:85202872777
SN - 0883-0738
JO - Journal of Child Neurology
JF - Journal of Child Neurology
ER -