Serial whole-brain N-acetylaspartate concentration in healthy young adults

D. J. Rigotti; M. Inglese; J. S. Babb; M. Rovaris; B. Benedetti; M. Filippi; R. I. Grossman; Oded Gonen

doi:10.3174/ajnr.A0712

Serial whole-brain N-acetylaspartate concentration in healthy young adults

D. J. Rigotti, M. Inglese, J. S. Babb, M. Rovaris, B. Benedetti, M. Filippi, R. I. Grossman, Oded Gonen

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Although the concentration of N-acetylaspartate (NAA) is often used as a neuronal integrity marker, its normal temporal variations are not well documented. To assess them over the 1-2 year periods of typical clinical trials, the whole-brain NAA concentration was measured longitudinally, over 4 years, in a cohort of healthy young adults. No significant change (adjusted for both sex and age) was measured either interpersonally or intrapersonally over the entire duration of the study.

Original language	English
Pages (from-to)	1650-1651
Number of pages	2
Journal	American Journal of Neuroradiology
Volume	28
Issue number	9
DOIs	https://doi.org/10.3174/ajnr.A0712
State	Published - Oct 2007
Externally published	Yes

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AU - Benedetti, B.

AU - Filippi, M.

AU - Grossman, R. I.

AU - Gonen, Oded

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AB - Although the concentration of N-acetylaspartate (NAA) is often used as a neuronal integrity marker, its normal temporal variations are not well documented. To assess them over the 1-2 year periods of typical clinical trials, the whole-brain NAA concentration was measured longitudinally, over 4 years, in a cohort of healthy young adults. No significant change (adjusted for both sex and age) was measured either interpersonally or intrapersonally over the entire duration of the study.

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Serial whole-brain N-acetylaspartate concentration in healthy young adults

Abstract

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