@article{be0a3f6cbefa4566a63e7e3f5b7e5271,
title = "Serial [18F]N-methylspiroperidol PET studies to measure changes in antipsychotic drug D-2 receptor occupancy in schizophrenic patients",
abstract = "An indirect approach to the relationship among drug dose, plasma level, and the competition between a labeled neuroleptic drug [18F]N-methylspiroperidol (18F-NMS) for binding sites in striatal tissue in normal and schizophrenic subjects is described. The slope of the line plotting the ratio of activity in the striatum (As) to activity in the cerebellum (Ac) versus time up to 5 hr postinjection of 18F-NMS is taken as a marker of site occupancy. An inverse relation between labeled competitor uptake and drug plasma level has been demonstrated for the classes of antipsychotic drug studied. Striatal uptake studies showed a progressive increase in all subjects following drug withdrawal up to 156 hr postwithdrawal. Uptake and clearance of 18F-NMS in cerebellar tissue was not appreciably affected by antipsychotic medication or drug withdrawal.",
author = "M. Smith and Wolf, \{A. P.\} and Brodie, \{J. D.\} and Arnett, \{C. D.\} and F. Barouche and Shiue, \{C. Y.\} and Fowler, \{J. S.\} and Russell, \{J. A.G.\} and MacGregor, \{R. R.\} and A. Wolkin and B. Angrist and J. Rotrosen and E. Peselow",
note = "Funding Information: From the Department of Psychiatry, State University of New York, Stony Brook, NY (MS.); the Department of Chemistry, B\textasciitilde{}\textasciitilde{}kh\textasciitilde{}\textasciitilde{}\textasciitilde{}nNationalLaboratory,Upton.NY(A.P.W..C.D.A.,C.Y.S..J.S.F.,J.A.G.R.,R.R.M.);andtheDepartment of Psychiatry. NYU Medical Center, New York, NY (J.D.B.. F.B., A.W., B.A.. J.R., E.P.). Supponed in part by U.S. Department of Energy Contract DE-AC02-76CH00016 (to Brookhaven) and by NIH Grants NS-15638 and NS-15380. Address reprint requestst o Dr. Alfred P. Wolf, Chemistry Department, BrookhavenN ational Laboratory, Upton, NY I 1973. Received January 5. 1987; revised August 19, 1987.",
year = "1988",
month = apr,
day = "1",
doi = "10.1016/0006-3223(88)90048-0",
language = "English",
volume = "23",
pages = "653--663",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier Inc.",
number = "7",
}