Serial analyis of melanoma growth kinetics in a patient receiving bleomycin and procarbazine therapy: Comparison of tumor volume, flow cytometry, and thymidine labeling techniques

J. J. Stragand; B. Drewinko; B. Barlogie

Serial analyis of melanoma growth kinetics in a patient receiving bleomycin and procarbazine therapy: Comparison of tumor volume, flow cytometry, and thymidine labeling techniques

J. J. Stragand, B. Drewinko, B. Barlogie

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4 Scopus citations

Abstract

A serial growth-kinetics analysis of the tumor of a patient with melanoma who was receiving bleomycin and procarbazine demonstrated significant reduction in cell proliferation. This reduction was followed by prompt proliferative recovery, which involved a parasynchronous movement of cells from G₁→DNA→mitosis. However, no change in the mean tumor volume of 35 cutaneous lesions was observed during or after treatment. These results suggest that tumor volume measurements alone do not provide a complete evaluation of chemotherapeutic response and/or drug efficacy.

Original language	English
Pages (from-to)	529-534
Number of pages	6
Journal	Cancer Treatment Reports
Volume	66
Issue number	3
State	Published - 1982
Externally published	Yes

Cite this

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title = "Serial analyis of melanoma growth kinetics in a patient receiving bleomycin and procarbazine therapy: Comparison of tumor volume, flow cytometry, and thymidine labeling techniques",

abstract = "A serial growth-kinetics analysis of the tumor of a patient with melanoma who was receiving bleomycin and procarbazine demonstrated significant reduction in cell proliferation. This reduction was followed by prompt proliferative recovery, which involved a parasynchronous movement of cells from G1→DNA→mitosis. However, no change in the mean tumor volume of 35 cutaneous lesions was observed during or after treatment. These results suggest that tumor volume measurements alone do not provide a complete evaluation of chemotherapeutic response and/or drug efficacy.",

author = "Stragand, \{J. J.\} and B. Drewinko and B. Barlogie",

year = "1982",

language = "English",

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journal = "Cancer Treatment Reports",

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T1 - Serial analyis of melanoma growth kinetics in a patient receiving bleomycin and procarbazine therapy

T2 - Comparison of tumor volume, flow cytometry, and thymidine labeling techniques

AU - Stragand, J. J.

AU - Drewinko, B.

AU - Barlogie, B.

PY - 1982

Y1 - 1982

N2 - A serial growth-kinetics analysis of the tumor of a patient with melanoma who was receiving bleomycin and procarbazine demonstrated significant reduction in cell proliferation. This reduction was followed by prompt proliferative recovery, which involved a parasynchronous movement of cells from G1→DNA→mitosis. However, no change in the mean tumor volume of 35 cutaneous lesions was observed during or after treatment. These results suggest that tumor volume measurements alone do not provide a complete evaluation of chemotherapeutic response and/or drug efficacy.

AB - A serial growth-kinetics analysis of the tumor of a patient with melanoma who was receiving bleomycin and procarbazine demonstrated significant reduction in cell proliferation. This reduction was followed by prompt proliferative recovery, which involved a parasynchronous movement of cells from G1→DNA→mitosis. However, no change in the mean tumor volume of 35 cutaneous lesions was observed during or after treatment. These results suggest that tumor volume measurements alone do not provide a complete evaluation of chemotherapeutic response and/or drug efficacy.

UR - https://www.scopus.com/pages/publications/0020001926

M3 - Article

C2 - 6174229

AN - SCOPUS:0020001926

SN - 0361-5960

VL - 66

SP - 529

EP - 534

JO - Cancer Treatment Reports

JF - Cancer Treatment Reports

IS - 3

ER -

Serial analyis of melanoma growth kinetics in a patient receiving bleomycin and procarbazine therapy: Comparison of tumor volume, flow cytometry, and thymidine labeling techniques

Abstract

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