Sequestration from immune CD4+ T cells of mycobacteria growing in human macrophages

Preeti Pancholi, Asra Mirza, Nina Bhardwaj, Ralph M. Steinman

Research output: Contribution to journalArticlepeer-review

163 Scopus citations

Abstract

CD4+ helper T cells mediate resistance to tuberculosis, presumably by enhancing the antimicrobial activity of macrophages within which the Mycobacterium tuberculosis organism grows. A first step in resistance should be the presentation of mycobacterial antigens by macrophages to CD4+ T cells. However, when the antigenic stimulus is limited to organisms growing in human monocytes, the organisms become sequestered from immune CD4+ T cells. This block in presentation is selective for growing mycobacteria and not for other stimuli. Sequestration would allow replicating organisms to persist in infected individuals and may contribute to virulence.

Original languageEnglish
Pages (from-to)984-986
Number of pages3
JournalScience
Volume260
Issue number5110
StatePublished - 1993
Externally publishedYes

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