TY - JOUR
T1 - Separation and determination of urinary homovanillic acid and iso-homovanillic acid by gas-liquid chromatography and electron capture detection
AU - Dziedzic, Stanley W.
AU - Dziedzic, Laura Bertani
AU - Gitlow, Stanley E.
PY - 1973/11
Y1 - 1973/11
N2 - Separation and detection of homovanillic acid (HVA) and 3-hydroxy-4-methoxyphenylacetic acid (iso-HVA) were achieved by gas-liquid chromatography and electron capture detection. Urines from 20 normal subjects, 18 children with neuroblastoma, and 7 patients with Parkinson's disease before and during l-dopa treatment were evaluated for both HVA and iso-HVA. The mean normal value obtained for HVA was 3.72 μg per milligram creatinine while that for iso-HVA was 0.28 μg per milligram creatinine. Increased HVA and iso-HVA were observed in patients with neuroblastoma while untreated Parkinson's disease patients had slightly elevated levels of HVA and markedly diminished iso-HVA levels. Although both compounds increased after L-dopa therapy, the elevation of iso-HVA was more marked than that of HVA.
AB - Separation and detection of homovanillic acid (HVA) and 3-hydroxy-4-methoxyphenylacetic acid (iso-HVA) were achieved by gas-liquid chromatography and electron capture detection. Urines from 20 normal subjects, 18 children with neuroblastoma, and 7 patients with Parkinson's disease before and during l-dopa treatment were evaluated for both HVA and iso-HVA. The mean normal value obtained for HVA was 3.72 μg per milligram creatinine while that for iso-HVA was 0.28 μg per milligram creatinine. Increased HVA and iso-HVA were observed in patients with neuroblastoma while untreated Parkinson's disease patients had slightly elevated levels of HVA and markedly diminished iso-HVA levels. Although both compounds increased after L-dopa therapy, the elevation of iso-HVA was more marked than that of HVA.
UR - http://www.scopus.com/inward/record.url?scp=0015804050&partnerID=8YFLogxK
M3 - Article
C2 - 4746822
AN - SCOPUS:0015804050
SN - 0022-2143
VL - 82
SP - 829
EP - 835
JO - Translational Research
JF - Translational Research
IS - 5
ER -