Sensory neuronopathy and small cell lung cancer. Antineuronal antibody that also reacts with the tumor

Francesc Graus; Keith B. Elkon; Carlos Cordon-Cardo; Jerome B. Posner

doi:10.1016/0002-9343(86)90047-1

Sensory neuronopathy and small cell lung cancer. Antineuronal antibody that also reacts with the tumor

Francesc Graus, Keith B. Elkon, Carlos Cordon-Cardo, Jerome B. Posner

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Abstract

An autoantibody highly restricted to the nuclei of neurons was found in four patients with subacute sensory neuronopathy and small cell carcinoma of the lung. The antibody was not found in normal subjects or patients with or without cancer who did not have subacute sensory neuronopathy. One- and two-dimensional immunoblotting analysis of nuclear extracts of rat and human brain identified an antibody reactive with a 35-38 kilodalton (kd) basic nucleoprotein. An identical protein lacking the 38 kd peptide was identified in tumor extract of one of the patients. All four patients' serum reacted with the same antigen in the brain and the tumor. In the postmortem study of one of the patients, IgG was found within the neurons of the dorsal root ganglia by direct immunofluorescence. These findings support the hypothesis that the subacute sensory neuronopathy is caused by an antibody that cross-reacts with a tumor cell antigen and a brain nucleoprotein.

Original language	English
Pages (from-to)	45-52
Number of pages	8
Journal	American Journal of Medicine
Volume	80
Issue number	1
DOIs	https://doi.org/10.1016/0002-9343(86)90047-1
State	Published - Jan 1986
Externally published	Yes

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title = "Sensory neuronopathy and small cell lung cancer. Antineuronal antibody that also reacts with the tumor",

abstract = "An autoantibody highly restricted to the nuclei of neurons was found in four patients with subacute sensory neuronopathy and small cell carcinoma of the lung. The antibody was not found in normal subjects or patients with or without cancer who did not have subacute sensory neuronopathy. One- and two-dimensional immunoblotting analysis of nuclear extracts of rat and human brain identified an antibody reactive with a 35-38 kilodalton (kd) basic nucleoprotein. An identical protein lacking the 38 kd peptide was identified in tumor extract of one of the patients. All four patients' serum reacted with the same antigen in the brain and the tumor. In the postmortem study of one of the patients, IgG was found within the neurons of the dorsal root ganglia by direct immunofluorescence. These findings support the hypothesis that the subacute sensory neuronopathy is caused by an antibody that cross-reacts with a tumor cell antigen and a brain nucleoprotein.",

author = "Francesc Graus and Elkon, {Keith B.} and Carlos Cordon-Cardo and Posner, {Jerome B.}",

note = "Funding Information: From the Departments of Neurology and Pathology, Memorial Sloan-Kettering Cancer Center, the Division of Rheumatic Diseases, The Hospital for Special Surgery, and the Departments of Neurology and Medicine, Cornell University Medical College, New York, New York. This work was supported in part by National Institutes of Health Grants AM32845 and AM14627. Requests for reprints should be addressed to Dr. Jerome 6. Posner, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021. Manuscript accepted August 30, 1985.",

year = "1986",

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doi = "10.1016/0002-9343(86)90047-1",

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AU - Graus, Francesc

AU - Elkon, Keith B.

AU - Cordon-Cardo, Carlos

AU - Posner, Jerome B.

N1 - Funding Information: From the Departments of Neurology and Pathology, Memorial Sloan-Kettering Cancer Center, the Division of Rheumatic Diseases, The Hospital for Special Surgery, and the Departments of Neurology and Medicine, Cornell University Medical College, New York, New York. This work was supported in part by National Institutes of Health Grants AM32845 and AM14627. Requests for reprints should be addressed to Dr. Jerome 6. Posner, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021. Manuscript accepted August 30, 1985.

PY - 1986/1

Y1 - 1986/1

N2 - An autoantibody highly restricted to the nuclei of neurons was found in four patients with subacute sensory neuronopathy and small cell carcinoma of the lung. The antibody was not found in normal subjects or patients with or without cancer who did not have subacute sensory neuronopathy. One- and two-dimensional immunoblotting analysis of nuclear extracts of rat and human brain identified an antibody reactive with a 35-38 kilodalton (kd) basic nucleoprotein. An identical protein lacking the 38 kd peptide was identified in tumor extract of one of the patients. All four patients' serum reacted with the same antigen in the brain and the tumor. In the postmortem study of one of the patients, IgG was found within the neurons of the dorsal root ganglia by direct immunofluorescence. These findings support the hypothesis that the subacute sensory neuronopathy is caused by an antibody that cross-reacts with a tumor cell antigen and a brain nucleoprotein.

AB - An autoantibody highly restricted to the nuclei of neurons was found in four patients with subacute sensory neuronopathy and small cell carcinoma of the lung. The antibody was not found in normal subjects or patients with or without cancer who did not have subacute sensory neuronopathy. One- and two-dimensional immunoblotting analysis of nuclear extracts of rat and human brain identified an antibody reactive with a 35-38 kilodalton (kd) basic nucleoprotein. An identical protein lacking the 38 kd peptide was identified in tumor extract of one of the patients. All four patients' serum reacted with the same antigen in the brain and the tumor. In the postmortem study of one of the patients, IgG was found within the neurons of the dorsal root ganglia by direct immunofluorescence. These findings support the hypothesis that the subacute sensory neuronopathy is caused by an antibody that cross-reacts with a tumor cell antigen and a brain nucleoprotein.

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JF - American Journal of Medicine

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Sensory neuronopathy and small cell lung cancer. Antineuronal antibody that also reacts with the tumor

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