Abstract
Epithelial barriers such as the skin, lung, and gut, in addition to having unique physiologic functions, are designed to preserve tissue homeostasis upon challenge with a variety of allergens, irritants, or pathogens. Both the innate and adaptive immune systems play a critical role in responding to epithelial cues triggered by environmental stimuli. However, the mechanisms by which organs sense and coordinate complex epithelial, stromal, and immune responses have remained a mystery. Our increasing understanding of the anatomic and functional characteristics of the sensory nervous system is greatly advancing a new field of peripheral neuroimmunology and subsequently changing our understanding of mucosal immunology. Herein, we detail how sensory biology is informing mucosal neuroimmunology, even beyond neuroimmune interactions seen within the central and autonomic nervous systems.
Original language | English |
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Pages (from-to) | 1151-1160 |
Number of pages | 10 |
Journal | Mucosal Immunology |
Volume | 17 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2024 |
Keywords
- Itch
- Mast cells
- Mrgpr
- Nociceptor
- Peripheral neuroimmmunology
- Pruriceptor
- Sensory biology
- TRP channel