Sensory abnormalities in unaffected relatives in familial adult-onset dystonia

J. P. O'Dwyer; S. O'Riordan; R. Saunders-Pullman; S. B. Bressman; F. Molloy; T. Lynch; M. Hutchinson

doi:10.1212/01.wnl.0000176068.23983.a8

Sensory abnormalities in unaffected relatives in familial adult-onset dystonia

J. P. O'Dwyer, S. O'Riordan, R. Saunders-Pullman, S. B. Bressman, F. Molloy, T. Lynch, M. Hutchinson

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Somatosensory abnormalities are found in adult-onset primary torsion dystonia (PTD). Therefore we assessed spatial discrimination thresholds (SDT), a measure of spatial acuity, in four multiplex families with adult-onset PTD. In family members aged 20 to 45 years vs controls (mean + 2.5 SD), abnormal SDTs were found in four of five affected with adult-onset PTD and in 12 of 49 unaffected relatives. Sensory abnormalities may be an endophenotype, possibly expressed later as adult-onset PTD.

Original language	English
Pages (from-to)	938-940
Number of pages	3
Journal	Neurology
Volume	65
Issue number	6
DOIs	https://doi.org/10.1212/01.wnl.0000176068.23983.a8
State	Published - 27 Sep 2005
Externally published	Yes

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title = "Sensory abnormalities in unaffected relatives in familial adult-onset dystonia",

abstract = "Somatosensory abnormalities are found in adult-onset primary torsion dystonia (PTD). Therefore we assessed spatial discrimination thresholds (SDT), a measure of spatial acuity, in four multiplex families with adult-onset PTD. In family members aged 20 to 45 years vs controls (mean + 2.5 SD), abnormal SDTs were found in four of five affected with adult-onset PTD and in 12 of 49 unaffected relatives. Sensory abnormalities may be an endophenotype, possibly expressed later as adult-onset PTD.",

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T1 - Sensory abnormalities in unaffected relatives in familial adult-onset dystonia

AU - O'Dwyer, J. P.

AU - O'Riordan, S.

AU - Saunders-Pullman, R.

AU - Bressman, S. B.

AU - Molloy, F.

AU - Lynch, T.

AU - Hutchinson, M.

PY - 2005/9/27

Y1 - 2005/9/27

N2 - Somatosensory abnormalities are found in adult-onset primary torsion dystonia (PTD). Therefore we assessed spatial discrimination thresholds (SDT), a measure of spatial acuity, in four multiplex families with adult-onset PTD. In family members aged 20 to 45 years vs controls (mean + 2.5 SD), abnormal SDTs were found in four of five affected with adult-onset PTD and in 12 of 49 unaffected relatives. Sensory abnormalities may be an endophenotype, possibly expressed later as adult-onset PTD.

AB - Somatosensory abnormalities are found in adult-onset primary torsion dystonia (PTD). Therefore we assessed spatial discrimination thresholds (SDT), a measure of spatial acuity, in four multiplex families with adult-onset PTD. In family members aged 20 to 45 years vs controls (mean + 2.5 SD), abnormal SDTs were found in four of five affected with adult-onset PTD and in 12 of 49 unaffected relatives. Sensory abnormalities may be an endophenotype, possibly expressed later as adult-onset PTD.

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U2 - 10.1212/01.wnl.0000176068.23983.a8

DO - 10.1212/01.wnl.0000176068.23983.a8

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SN - 0028-3878

VL - 65

SP - 938

EP - 940

JO - Neurology

JF - Neurology

IS - 6

ER -

Sensory abnormalities in unaffected relatives in familial adult-onset dystonia

Abstract

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