Senesce to Survive: YAP-Mediated Dormancy Escapes EGFR/MEK Inhibition

Igor Bado, Xiang H.F. Zhang

Research output: Contribution to journalComment/debate

5 Scopus citations

Abstract

Therapeutic resistance is a major challenge in cancer treatment. In this issue of Cancer Cell, Kurppa et al. demonstrated that a senescence-like state enables lung cancer cells to survive dual inhibition of EGFR and MEK. This was mediated by the YAP/TEAD pathway, which drives epigenomic reprogramming and EMT to counteract apoptosis.

Original languageEnglish
Pages (from-to)1-2
Number of pages2
JournalCancer Cell
Volume37
Issue number1
DOIs
StatePublished - 13 Jan 2020
Externally publishedYes

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