Semi-automated 3d volumetric renal measurements in polycystic kidney disease using b0-images—a feasibility study

Alexandra Roudenko, Soran Mahmood, Linda Du, Drew Gunio, Irina Barash, Florence Doo, Alon Slutzky, Nina Kukar, Barak Friedman, Alexander Kagen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Autosomal dominant polycystic kidney disease (ADPKD) eventually leads to end stage renal disease (ESRD) with an increase in size and number of cysts over time. Progression to ESRD has previously been shown to correlate with total kidney volume (TKV). An accurate and relatively simple method to perform measurement of TKV has been difficult to develop. We propose a semiautomated approach of calculating TKV inclusive of all cysts in ADPKD patients based on b0 images relatively quickly without requiring any calculations or additional MRI time. Our purpose is to evaluate the reliability and reproducibility of our method by raters of various training levels within the environment of an advanced 3D viewer. Thirty patients were retrospectively identified who had DWI performed as part of 1.5T MRI renal examination. Right and left TKVs were calculated by five radiologists of various training levels. Interrater reliability (IRR) was estimated by computing the intraclass correlation (ICC) for all raters. ICC values calculated for TKV measurements between the five raters were 0.989 (95% CI = (0.981, 0.994), p < 0.01) for the right and 0.961 (95% CI = (0.936, 0.979), p < 0.01) for the left. Our method shows excellent intraclass correlation between raters, allowing for excellent interrater reliability.

Original languageEnglish
Pages (from-to)573-580
Number of pages8
Issue number4
StatePublished - 1 Dec 2021
Externally publishedYes


  • B0
  • Kidney volume
  • MRI
  • Polycystic kidney disease


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