TY - JOUR
T1 - Self-regulating genes. Exact steady state solution by using Poisson representation
AU - Sugár, István P.
AU - Simon, István
N1 - Funding Information:
I.P.S. acknowledges the support by contract NIH/NIAID HHSN272201000054C. I.S. acknowledges the support from the Hungarian Science Research Fund (OTKA-NK 100482).
PY - 2014/9
Y1 - 2014/9
N2 - Systems biology studies the structure and behavior of complex gene regulatory networks. One of its aims is to develop a quantitative understanding of the modular components that constitute such networks. The self-regulating gene is a type of auto regulatory genetic modules which appears in over 40% of known transcription factors in E. coli. In this work, using the technique of Poisson Representation, we are able to provide exact steady state solutions for this feedback model. By using the methods of synthetic biology (P.E.M. Purnick and Weiss, R., Nature Reviews, Molecular Cell Biology, 2009, 10: 410-422) one can build the system itself from modules like this.
AB - Systems biology studies the structure and behavior of complex gene regulatory networks. One of its aims is to develop a quantitative understanding of the modular components that constitute such networks. The self-regulating gene is a type of auto regulatory genetic modules which appears in over 40% of known transcription factors in E. coli. In this work, using the technique of Poisson Representation, we are able to provide exact steady state solutions for this feedback model. By using the methods of synthetic biology (P.E.M. Purnick and Weiss, R., Nature Reviews, Molecular Cell Biology, 2009, 10: 410-422) one can build the system itself from modules like this.
KW - Poisson representation
KW - genetics
KW - master equations
KW - probability distribution
UR - http://www.scopus.com/inward/record.url?scp=84905173885&partnerID=8YFLogxK
U2 - 10.2478/s11534-014-0497-0
DO - 10.2478/s11534-014-0497-0
M3 - Article
AN - SCOPUS:84905173885
SN - 1895-1082
VL - 12
SP - 615
EP - 627
JO - Central European Journal of Physics
JF - Central European Journal of Physics
IS - 9
ER -