Self-assembling tryptophan-based designer peptides as intracellular delivery vehicles

Ishanki Bhardwaj, Divya Jha, Prasad Admane, Amulya K. Panda, V. Haridas

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A series of tryptophan-based peptides W1a, b-W4a, b, with diverse architectures were designed and synthesized. These tryptophan containing peptides can self-assemble to spherical particle. This self-assembled system was demonstrated to encapsulate rhodamine B and penetrate the cell membrane.

Original languageEnglish
Pages (from-to)672-676
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number2
DOIs
StatePublished - 15 Jan 2016
Externally publishedYes

Keywords

  • Encapsulation
  • Peptide
  • Self-assembly
  • Spherical assembly
  • Tryptophan

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