Selective opioid receptor antagonist effects upon intake of a high-fat diet in rats

Anita K. Islam, Richard J. Bodnar

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Short-term (2 h) intake of a high-fat diet in rats was significantly inhibited by intravenous (0.1-10 mg/kg: 39-67%) and central (1-5 μg, i.c.v.: 51%) naloxone. The irreversible mu opioid antagonist, beta-funaltrexamine (10 μg, i.c.v.: 37%), but not the irreversible mu1 antagonists naloxonazine (10 mg/kg, i.v.) inhibited intake, suggesting mu2 receptor mediation. The delta antagonist, ICI 174864 (1-10 μg, i.c.v.: 41%) inhibited high-fat diet intake only at doses that also produced motor dysfunction.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalBrain Research
Volume508
Issue number2
DOIs
StatePublished - 5 Feb 1990
Externally publishedYes

Keywords

  • High-fat diet
  • Opioid receptor
  • Palatability
  • δ-Receptor
  • μ-Receptor

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