Short-term (2 h) intake of a high-fat diet in rats was significantly inhibited by intravenous (0.1-10 mg/kg: 39-67%) and central (1-5 μg, i.c.v.: 51%) naloxone. The irreversible mu opioid antagonist, beta-funaltrexamine (10 μg, i.c.v.: 37%), but not the irreversible mu1 antagonists naloxonazine (10 mg/kg, i.v.) inhibited intake, suggesting mu2 receptor mediation. The delta antagonist, ICI 174864 (1-10 μg, i.c.v.: 41%) inhibited high-fat diet intake only at doses that also produced motor dysfunction.
- High-fat diet
- Opioid receptor