TY - JOUR
T1 - Selective killing of T lymphocytes by phototoxic liposomes
AU - Yemul, S.
AU - Berger, C.
AU - Estabrook, A.
AU - Suarez, S.
AU - Edelson, R.
AU - Bayley, H.
PY - 1987
Y1 - 1987
N2 - Two-fold specificity in drug delivery obtained through (i) the localized activation of drugs by physical means and (ii) the attachment of drugs to proteins that bind to target cells might be used for highly selective cancer chemotherapy or for immunosuppression. Toward this end, a monoclonal antibody against an antigen on the surface of T lymphocytes was covalently attached to liposomes containing a phototoxic drug, pyrene, bound to the lipid bilayer. When unfractionated peripheral blood lymphocytes, or B- and T-cell lines, were irradiated after treatment with these liposomes, T cells were killed while B cells were spared, demonstrated the validity of the approach in a simple in vitro assay.
AB - Two-fold specificity in drug delivery obtained through (i) the localized activation of drugs by physical means and (ii) the attachment of drugs to proteins that bind to target cells might be used for highly selective cancer chemotherapy or for immunosuppression. Toward this end, a monoclonal antibody against an antigen on the surface of T lymphocytes was covalently attached to liposomes containing a phototoxic drug, pyrene, bound to the lipid bilayer. When unfractionated peripheral blood lymphocytes, or B- and T-cell lines, were irradiated after treatment with these liposomes, T cells were killed while B cells were spared, demonstrated the validity of the approach in a simple in vitro assay.
UR - http://www.scopus.com/inward/record.url?scp=0041375742&partnerID=8YFLogxK
U2 - 10.1073/pnas.84.1.246
DO - 10.1073/pnas.84.1.246
M3 - Article
C2 - 3491992
AN - SCOPUS:0041375742
SN - 0027-8424
VL - 84
SP - 246
EP - 250
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 1
ER -