Selective hippocampal subfield volume reductions in world trade center responders with cognitive impairment

Yael Deri, Sean A.P. Clouston, Christine Delorenzo, John D. Gardus, Megan Horton, Cheuk Tang, Alison C. Pellecchia, Stephanie Santiago-Michels, Melissa A. Carr, Sam Gandy, Mary Sano, Evelyn J. Bromet, Roberto G. Lucchini, Benjamin J. Luft

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Introduction: The objective of this study was to investigate associations between dementia in World Trade Center (WTC) responders and in vivo volumetric measures of hippocampal subfield volumes in WTC responders at midlife. Methods: A sample of 99 WTC responders was divided into dementia and unimpaired groups. Participants underwent structural T1-weighted magnetic resonance imaging. Volumetric measures included the overall hippocampus and eight subfields. Regression models examined volumetric measure of interest adjusting for confounders including intracranial volume. Results: Dementia was associated with smaller hippocampal volume and with reductions across hippocampal subfields. Smaller hippocampal subfield volumes were associated with longer cumulative time worked at the WTC. Domain-specific cognitive performance was associated with lower volumetric measures across hippocampal subregions. Conclusions: This is the first study to investigate hippocampal subfield volumes in a sample of WTC responders at midlife. Selective hippocampal subfield volume reductions suggested abnormal cognition that were associated with WTC exposure duration.

Original languageEnglish
Article numbere12165
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume13
Issue number1
DOIs
StatePublished - 2021

Keywords

  • Cognitive impairment
  • Hippocampal subfields
  • Post-traumatic stress disorder
  • World Trade Center responder

Fingerprint

Dive into the research topics of 'Selective hippocampal subfield volume reductions in world trade center responders with cognitive impairment'. Together they form a unique fingerprint.

Cite this