@article{4d17e1e706054516bbb39bdd47770673,
title = "Selective hippocampal subfield volume reductions in world trade center responders with cognitive impairment",
abstract = "Introduction: The objective of this study was to investigate associations between dementia in World Trade Center (WTC) responders and in vivo volumetric measures of hippocampal subfield volumes in WTC responders at midlife. Methods: A sample of 99 WTC responders was divided into dementia and unimpaired groups. Participants underwent structural T1-weighted magnetic resonance imaging. Volumetric measures included the overall hippocampus and eight subfields. Regression models examined volumetric measure of interest adjusting for confounders including intracranial volume. Results: Dementia was associated with smaller hippocampal volume and with reductions across hippocampal subfields. Smaller hippocampal subfield volumes were associated with longer cumulative time worked at the WTC. Domain-specific cognitive performance was associated with lower volumetric measures across hippocampal subregions. Conclusions: This is the first study to investigate hippocampal subfield volumes in a sample of WTC responders at midlife. Selective hippocampal subfield volume reductions suggested abnormal cognition that were associated with WTC exposure duration.",
keywords = "Cognitive impairment, Hippocampal subfields, Post-traumatic stress disorder, World Trade Center responder",
author = "Yael Deri and Clouston, {Sean A.P.} and Christine Delorenzo and Gardus, {John D.} and Megan Horton and Cheuk Tang and Pellecchia, {Alison C.} and Stephanie Santiago-Michels and Carr, {Melissa A.} and Sam Gandy and Mary Sano and Bromet, {Evelyn J.} and Lucchini, {Roberto G.} and Luft, {Benjamin J.}",
note = "Funding Information: Centers for Disease Control and Prevention, Grant/Award Number: CDC/NIOSH U01 OH011314; National Institutes for Health, Grant/Award Numbers: NIH/NIA P50 AG005138, NIH/NIA R01 AG049953; World Trade Center, Grant/Award Number: CDC 200-2011-39361 The authors would like to acknowledge support from the Centers for Disease Control and Prevention for supporting the neuroimaging study (CDC/NIOSH U01 OH011314), the National Institutes for Health (NIH/NIA P50 AG005138, NIH/NIA R01 AG049953), and for the clinical monitoring program for World Trade Center responders (CDC 200-2011-39361). The authors would like to thank all the participants. We also thank Dr. Monika A. Waszczuk for her assistance in formulating the statistical analysis plan for this manuscript. Funding Information: The authors would like to acknowledge support from the Centers for Disease Control and Prevention for supporting the neuroimag-ing study (CDC/NIOSH U01 OH011314), the National Institutes for Health (NIH/NIA P50 AG005138, NIH/NIA R01 AG049953), and for the clinical monitoring program for World Trade Center responders (CDC 200-2011-39361). The authors would like to thank all the participants. We also thank Dr. Monika A. Waszczuk for her assistance in formulating the statistical analysis plan for this manuscript. Publisher Copyright: {\textcopyright} 2021 The Authors.",
year = "2021",
doi = "10.1002/dad2.12165",
language = "English",
volume = "13",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "John Wiley & Sons Inc.",
number = "1",
}