Selective fetal malnutrition: The effect of ethanol and acetaldehyde upon in vitro uptake of alpha amino isobutyric acid by human placenta

Stanley E. Fisher; Mark Atkinson; David H. Van Thiel; Elaine Rosenblum; Ron David; Ian Holzman

doi:10.1016/0024-3205(81)90235-6

Selective fetal malnutrition: The effect of ethanol and acetaldehyde upon in vitro uptake of alpha amino isobutyric acid by human placenta

Stanley E. Fisher, Mark Atkinson, David H. Van Thiel, Elaine Rosenblum, Ron David, Ian Holzman

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31 Scopus citations

Abstract

Uptake of alpha amino isobutyric acid was measured in human placental villus tissue exposed in vitro to ethyl alcohol (ethanol) (0.3 g/dl-2 g/d1) or acetaldehyde (50 μM-20 mM). Ethanol and acetaldehyde significantly inhibited uptake of amino acid at higher, pharmacologic concentrations (2 g/dl and 2-20 mM respectively). Inhibition by 10 mM acetaldehyde was partially reversible. The results suggest that the human placenta is resistant to acute ethanol-associated effects upon amino acid transport in vitro. However, both ethanol and its major circulating metabolite, acetaldehyde, may still alter placental function during in vivo chronic exposure.

Original language	English
Pages (from-to)	1283-1288
Number of pages	6
Journal	Life Sciences
Volume	29
Issue number	12
DOIs	https://doi.org/10.1016/0024-3205(81)90235-6
State	Published - 21 Sep 1981
Externally published	Yes

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title = "Selective fetal malnutrition: The effect of ethanol and acetaldehyde upon in vitro uptake of alpha amino isobutyric acid by human placenta",

abstract = "Uptake of alpha amino isobutyric acid was measured in human placental villus tissue exposed in vitro to ethyl alcohol (ethanol) (0.3 g/dl-2 g/d1) or acetaldehyde (50 μM-20 mM). Ethanol and acetaldehyde significantly inhibited uptake of amino acid at higher, pharmacologic concentrations (2 g/dl and 2-20 mM respectively). Inhibition by 10 mM acetaldehyde was partially reversible. The results suggest that the human placenta is resistant to acute ethanol-associated effects upon amino acid transport in vitro. However, both ethanol and its major circulating metabolite, acetaldehyde, may still alter placental function during in vivo chronic exposure.",

author = "Fisher, {Stanley E.} and Mark Atkinson and {Van Thiel}, {David H.} and Elaine Rosenblum and Ron David and Ian Holzman",

note = "Funding Information: This work was supported in part by grants from the Mary Hamilton and W. Clark Hagan Foundation, the Hunt Foundation, and the NIH (AA04425). The authors wish to thank Ms. Carleen Peppler and MS. Nancy Brown for their secretarial assistance.",

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doi = "10.1016/0024-3205(81)90235-6",

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T1 - Selective fetal malnutrition

T2 - The effect of ethanol and acetaldehyde upon in vitro uptake of alpha amino isobutyric acid by human placenta

AU - Fisher, Stanley E.

AU - Atkinson, Mark

AU - Van Thiel, David H.

AU - Rosenblum, Elaine

AU - David, Ron

AU - Holzman, Ian

N1 - Funding Information: This work was supported in part by grants from the Mary Hamilton and W. Clark Hagan Foundation, the Hunt Foundation, and the NIH (AA04425). The authors wish to thank Ms. Carleen Peppler and MS. Nancy Brown for their secretarial assistance.

PY - 1981/9/21

Y1 - 1981/9/21

N2 - Uptake of alpha amino isobutyric acid was measured in human placental villus tissue exposed in vitro to ethyl alcohol (ethanol) (0.3 g/dl-2 g/d1) or acetaldehyde (50 μM-20 mM). Ethanol and acetaldehyde significantly inhibited uptake of amino acid at higher, pharmacologic concentrations (2 g/dl and 2-20 mM respectively). Inhibition by 10 mM acetaldehyde was partially reversible. The results suggest that the human placenta is resistant to acute ethanol-associated effects upon amino acid transport in vitro. However, both ethanol and its major circulating metabolite, acetaldehyde, may still alter placental function during in vivo chronic exposure.

AB - Uptake of alpha amino isobutyric acid was measured in human placental villus tissue exposed in vitro to ethyl alcohol (ethanol) (0.3 g/dl-2 g/d1) or acetaldehyde (50 μM-20 mM). Ethanol and acetaldehyde significantly inhibited uptake of amino acid at higher, pharmacologic concentrations (2 g/dl and 2-20 mM respectively). Inhibition by 10 mM acetaldehyde was partially reversible. The results suggest that the human placenta is resistant to acute ethanol-associated effects upon amino acid transport in vitro. However, both ethanol and its major circulating metabolite, acetaldehyde, may still alter placental function during in vivo chronic exposure.

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Selective fetal malnutrition: The effect of ethanol and acetaldehyde upon in vitro uptake of alpha amino isobutyric acid by human placenta

Abstract

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