Selecting patients for breast conservation without radiation therapy

Dana Zappetti, Paul Ian Tartter, Steven T. Brower, Joan Bratton, Gerson Lesnick

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The majority of breast cancer patients treated with breast conservation without adjuvant radiation therapy do not develop local recurrences. We reviewed the results of breast conservation by the senior author for 198 consecutive cancers, 109 treated without radiation therapy, in order to identify patients at an acceptable risk of local recurrence treated without radiation. Using multivariate analysis, only stage was significantly (p = 0.014) related to distant disease-free survival. No single variable was significantly related to the risk of local recurrence, although radiation therapy was of borderline significance (p = 0.076). None of the 29 patients over 50 years of age with cancers measuring less than 1 cm in diameter removed by segmental resection or quadrantectomy (20 of 29 without radiation) developed a local recurrence compared to 16% of the remaining patients. This study indicates that it is possible to select patients for breast conservation without adjuvant radiation therapy at an acceptably low risk of local recurrence.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalBreast Disease
Volume9
Issue number4
StatePublished - Jul 1996

Keywords

  • Breast cancer
  • Breast conservation
  • Local recurrence
  • Radiation therapy

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