TY - JOUR
T1 - Selected persistent organic pollutants in human placental tissue from the United States
AU - Nanes, Jessica A.
AU - Xia, Yulin
AU - Dassanayake, R. M.A.Priyanthi S.
AU - Jones, Rachael M.
AU - Li, An
AU - Stodgell, Christopher J.
AU - Walker, Cheryl K.
AU - Szabo, Sara
AU - Leuthner, Steve
AU - Durkin, Maureen S.
AU - Moye, Jack
AU - Miller, Richard K.
N1 - Funding Information:
This work is part of the National Children’s Study Placenta Consortium (NCS formative research project LOI2-BIO-18). This work was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and funded, through its appropriation, by the Office of the Director of the National Institutes of Health, with NICHD Contracts HHSN267200700027C, HHSN275201100002C, and HHSN275200503396C. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health or the U.S. Department of Health and Human Services.
Funding Information:
The authors sincerely thank our fellow researchers of the LOI2-BIO-18 team as well as all the women who donated their placentae. We acknowledge the administrative support from the NCS Greater Chicago Study Center at the Northwestern University. The Consortium acknowledges the contributions of Amber Rinkerknecht, Linda Salamone, and Philip Weidenborner on behalf of this research and offers special acknowledgements to Tai Kwong and Alan Friedman for their review of the data and editorial comments.
PY - 2014/7
Y1 - 2014/7
N2 - Emerging and legacy environmental pollutants such as polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and organochlorine pesticide metabolite DDE are found in human placenta, indicating prenatal exposure, but data from the United States are sparse. We sought to determine concentrations of these compounds in human placentae as part of a formative research project conducted by the National Children's Study Placenta Consortium. A total of 169 tissue specimens were collected at different time points post delivery from 43 human placentae at three U.S. locations, and analyzed by gas chromatography coupled with mass spectrometry following extraction using matrix solid phase dispersion. PBDEs, PCBs, and DDE were detected in all specimens. The concentrations of 10 PBDEs (σ10PBDEs), 32 PCBs (σ32PCBs) and p,p'-DDE were 43-1723, 76-856 and 10-1968pgg-1 wet weight, respectively, in specimens collected shortly after delivery. Significant geographic differences in PBDEs were observed, with higher concentrations in placentae collected in Davis, CA than in those from Rochester, NY or Milwaukee, WI. We combined these with other published data and noted first-order declining trends for placental PCB and DDE concentrations over the past decades, with half-lives of about 5 and 8years, respectively. The effect of time to tissue collection from refrigerated placentae on measured concentrations of these three classes of persistent organic pollutants was additionally examined, with no significant effect observed up to 120h. The results of this work indicate that widespread prenatal exposure to persistent organic pollutants in the United States continues.
AB - Emerging and legacy environmental pollutants such as polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and organochlorine pesticide metabolite DDE are found in human placenta, indicating prenatal exposure, but data from the United States are sparse. We sought to determine concentrations of these compounds in human placentae as part of a formative research project conducted by the National Children's Study Placenta Consortium. A total of 169 tissue specimens were collected at different time points post delivery from 43 human placentae at three U.S. locations, and analyzed by gas chromatography coupled with mass spectrometry following extraction using matrix solid phase dispersion. PBDEs, PCBs, and DDE were detected in all specimens. The concentrations of 10 PBDEs (σ10PBDEs), 32 PCBs (σ32PCBs) and p,p'-DDE were 43-1723, 76-856 and 10-1968pgg-1 wet weight, respectively, in specimens collected shortly after delivery. Significant geographic differences in PBDEs were observed, with higher concentrations in placentae collected in Davis, CA than in those from Rochester, NY or Milwaukee, WI. We combined these with other published data and noted first-order declining trends for placental PCB and DDE concentrations over the past decades, with half-lives of about 5 and 8years, respectively. The effect of time to tissue collection from refrigerated placentae on measured concentrations of these three classes of persistent organic pollutants was additionally examined, with no significant effect observed up to 120h. The results of this work indicate that widespread prenatal exposure to persistent organic pollutants in the United States continues.
KW - Dichlorodiphenyldichloroethylene (DDE)
KW - Human placenta
KW - National Children's Study (NCS)
KW - Persistent organic pollutants
KW - Polybrominated diphenyl ethers (PBDEs)
KW - Polychlorinated biphenyls (PCBs)
UR - https://www.scopus.com/pages/publications/84896547894
U2 - 10.1016/j.chemosphere.2013.12.080
DO - 10.1016/j.chemosphere.2013.12.080
M3 - Article
C2 - 24485817
AN - SCOPUS:84896547894
SN - 0045-6535
VL - 106
SP - 20
EP - 27
JO - Chemosphere
JF - Chemosphere
ER -