Segmental Intestinal Absorption of Ranitidine: Investigative and Therapeutic Implications

Neil A. Halpern, Robert D. Colucci, Jonathan Turk, Jeffrey S. Freed, A. J. McElhinney, Allen Bishop, Robert Greenstein

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The absorption of ranitidine from different segments of the intestinal tract was studied in a subject who bad an anatomically divided small intestine. The results indicate that the drug is maximally absorbed from the small bowel rather than the stomach. Subsequent animal studies have shown that absorption of ranitidine in dogs is primarily duodenal followed by jejunal and ileal. The lack of gastric absorption, with predominantly small bowel absorption, may have investigational and therapeutic implications in a variety of gastrointestinal diseases.

Original languageEnglish
Pages (from-to)539-543
Number of pages5
JournalAmerican Journal of Gastroenterology
Issue number5
StatePublished - May 1990


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