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Secretion of Weibel-Palade bodies observed in extra-alveolar vessels of rabbit lung

  • J. M. McNiff
  • , J. Gil

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We fixed rabbit lungs by perfusion of osmium into the pulmonary artery and examined in light and transmission electron microscopy a large number of extra-alveolar vessels with a diameter of 0.1-0.25 mm, with emphasis on Weibel-Palade bodies (endothelial specific granules). Weibel-Palade bodies are organelles specific to endothelial cells. Their function is unknown, but they are useful markers for identification of endothelial cells in culture. We were able to observe release of the content of these bodies into the vascular lumen; this indicates that they are secretory.

Original languageEnglish
Pages (from-to)1284-1286
Number of pages3
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume54
Issue number5
DOIs
StatePublished - 1983
Externally publishedYes

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