TY - JOUR
T1 - Secondary Progressive Multiple Sclerosis
T2 - A Review of Clinical Characteristics, Definition, Prognostic Tools, and Disease-Modifying Therapies
AU - Ziemssen, Tjalf
AU - Bhan, Virender
AU - Chataway, Jeremy
AU - Chitnis, Tanuja
AU - Cree, Bruce Anthony Campbell
AU - Havrdova, Eva Kubala
AU - Kappos, Ludwig
AU - Labauge, Pierre
AU - Miller, Aaron
AU - Nakahara, Jin
AU - Oreja-Guevara, Celia
AU - Palace, Jacqueline
AU - Singer, Barry
AU - Trojano, Maria
AU - Patil, Ashwini
AU - Rauser, Benedict
AU - Hach, Thomas
N1 - Publisher Copyright:
© American Academy of Neurology.
PY - 2023/1/22
Y1 - 2023/1/22
N2 - Many challenges exist in the precise diagnosis and clinical management of secondary progressive multiple sclerosis (SPMS) because of the lack of definitive clinical, imaging, immunologic, or pathologic criteria that demarcate the transition from relapsing-remitting MS to SPMS. This review provides an overview of the diagnostic criteria/definition and the heterogeneity associated with different SPMS patient populations; it also emphasizes the importance of available prospective/retrospective tools to identify patients with SPMS earlier in the disease course so that approved disease-modifying therapies and nonpharmacological strategies will translate into better outcomes. Delivery of such interventions necessitates an evolving patient-clinician dialog within the context of a multidisciplinary team.
AB - Many challenges exist in the precise diagnosis and clinical management of secondary progressive multiple sclerosis (SPMS) because of the lack of definitive clinical, imaging, immunologic, or pathologic criteria that demarcate the transition from relapsing-remitting MS to SPMS. This review provides an overview of the diagnostic criteria/definition and the heterogeneity associated with different SPMS patient populations; it also emphasizes the importance of available prospective/retrospective tools to identify patients with SPMS earlier in the disease course so that approved disease-modifying therapies and nonpharmacological strategies will translate into better outcomes. Delivery of such interventions necessitates an evolving patient-clinician dialog within the context of a multidisciplinary team.
UR - http://www.scopus.com/inward/record.url?scp=85142510384&partnerID=8YFLogxK
U2 - 10.1212/NXI.0000000000200064
DO - 10.1212/NXI.0000000000200064
M3 - Review article
C2 - 36414428
AN - SCOPUS:85142510384
SN - 2332-7812
VL - 10
JO - Neurology: Neuroimmunology and NeuroInflammation
JF - Neurology: Neuroimmunology and NeuroInflammation
IS - 1
M1 - e200064
ER -