TY - JOUR
T1 - Second primary cancers among 109 000 cases of non-Hodgkin's lymphoma
AU - Brennan, P.
AU - Scélo, G.
AU - Hemminki, K.
AU - Mellemkjaer, L.
AU - Tracey, E.
AU - Andersen, A.
AU - Brewster, D. H.
AU - Pukkala, E.
AU - McBride, M. L.
AU - Kliewer, E. V.
AU - Tonita, J. V.
AU - Seow, A.
AU - Pompe-Kirn, V.
AU - Martos, C.
AU - Jonasson, J. G.
AU - Colin, D.
AU - Boffetta, P.
N1 - Funding Information:
This work was supported by a grant R03 CA101442-02 from the National Cancer Institute (P Brennan). G Scélo worked on this study during the tenure of a Special Training Award from the International Agency for Research on Cancer.
PY - 2005/7/11
Y1 - 2005/7/11
N2 - An analysis of other primary cancers in individuals with non-Hodgkin's lymphoma (NHL) can help to elucidate this cancer aetiology. In all, 109451 first primary NHL were included in a pooled analysis of 13 cancer registries. The observed numbers of second cancers were compared to the expected numbers derived from the age-, sex-, calendar period- and registry-specific incidence rates. We also calculated the standardised incidence ratios for NHL as a second primary after other cancers. There was a 47% (95% confidence interval 43-51%) overall increase in the risk of a primary cancer after NHL A strongly significant (P < 0.001) increase was observed for cancers of the lip, tongue, oropharynx*, stomach, small intestine, colon*, liver, nasal cavity*, lung, soft tissues*, skin melanoma*, nonmelanoma skin*, bladder*, kidney*, thyroid*, Hodgkin's lymphoma*, lymphoid leukaemia* and myeloid leukaemia. Non-Hodgkin's lymphoma as a second primary was increased after cancers marked with an asterisk. Patterns of risk indicate a treatment effect for lung, bladder, stomach, Hodgkin's lymphoma and myeloid leukaemia. Common risk factors may be involved for cancers of the lung, bladder, nasal cavity and for soft tissues, such as pesticides. Bidirectional effects for several cancer sites of potential viral origin argue strongly for a role for immune suppression in NHL.
AB - An analysis of other primary cancers in individuals with non-Hodgkin's lymphoma (NHL) can help to elucidate this cancer aetiology. In all, 109451 first primary NHL were included in a pooled analysis of 13 cancer registries. The observed numbers of second cancers were compared to the expected numbers derived from the age-, sex-, calendar period- and registry-specific incidence rates. We also calculated the standardised incidence ratios for NHL as a second primary after other cancers. There was a 47% (95% confidence interval 43-51%) overall increase in the risk of a primary cancer after NHL A strongly significant (P < 0.001) increase was observed for cancers of the lip, tongue, oropharynx*, stomach, small intestine, colon*, liver, nasal cavity*, lung, soft tissues*, skin melanoma*, nonmelanoma skin*, bladder*, kidney*, thyroid*, Hodgkin's lymphoma*, lymphoid leukaemia* and myeloid leukaemia. Non-Hodgkin's lymphoma as a second primary was increased after cancers marked with an asterisk. Patterns of risk indicate a treatment effect for lung, bladder, stomach, Hodgkin's lymphoma and myeloid leukaemia. Common risk factors may be involved for cancers of the lung, bladder, nasal cavity and for soft tissues, such as pesticides. Bidirectional effects for several cancer sites of potential viral origin argue strongly for a role for immune suppression in NHL.
KW - Cancer registries
KW - Non-Hodgkin's lymphoma
KW - Second primary cancers
UR - http://www.scopus.com/inward/record.url?scp=23144457283&partnerID=8YFLogxK
U2 - 10.1038/sj.bjc.6602654
DO - 10.1038/sj.bjc.6602654
M3 - Article
C2 - 15970927
AN - SCOPUS:23144457283
SN - 0007-0920
VL - 93
SP - 159
EP - 166
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 1
ER -