Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

Emmanuel J.H.J. Wiertz; Domenico Tortorella; Matthew Bogyo; Joyce Yu; Walther Mothes; Thomas R. Jones; Tom A. Rapoport; Hidde L. Ploegh

doi:10.1038/384432a0

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

Emmanuel J.H.J. Wiertz, Domenico Tortorella, Matthew Bogyo, Joyce Yu, Walther Mothes, Thomas R. Jones, Tom A. Rapoport, Hidde L. Ploegh

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968 Scopus citations

Abstract

The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.

Original language	English
Pages (from-to)	432-438
Number of pages	7
Journal	Nature
Volume	384
Issue number	6608
DOIs	https://doi.org/10.1038/384432a0
State	Published - 5 Dec 1996
Externally published	Yes

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title = "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction",

abstract = "The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.",

author = "Wiertz, {Emmanuel J.H.J.} and Domenico Tortorella and Matthew Bogyo and Joyce Yu and Walther Mothes and Jones, {Thomas R.} and Rapoport, {Tom A.} and Ploegh, {Hidde L.}",

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AU - Yu, Joyce

AU - Mothes, Walther

AU - Jones, Thomas R.

AU - Rapoport, Tom A.

AU - Ploegh, Hidde L.

PY - 1996/12/5

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AB - The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.

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Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

Abstract

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