Screening for metabolic dysfunction-associated fatty liver disease: Time to discard the emperor’s clothes of normal liver enzymes

Chen Xiao Huang, Xiao Dong Zhou, Calvin Q. Pan, Ming Hua Zheng

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most prevalent chronic liver condition worldwide. Current liver enzyme-based screening methods have limitations that may missed diagnoses and treatment delays. Regarding Chen et al, the risk of developing MAFLD remains elevated even when alanine aminotransferase levels fall within the normal range. Therefore, there is an urgent need for advanced diagnostic techniques and updated algorithms to enhance the accuracy of MAFLD diagnosis and enable early intervention. This paper proposes two potential screening methods for identifying individuals who may be at risk of developing MAFLD: Lowering these thresholds and promoting the use of noninvasive liver fibrosis scores.

Original languageEnglish
Pages (from-to)2839-2842
Number of pages4
JournalWorld Journal of Gastroenterology
Volume30
Issue number22
DOIs
StatePublished - 2024
Externally publishedYes

Keywords

  • Alanine aminotransferase
  • Liver enzymes
  • Metabolic dysfunction-associated fatty liver disease
  • Non-alcoholic fatty liver disease
  • Noninvasive liver fibrosis scores
  • Screening

Fingerprint

Dive into the research topics of 'Screening for metabolic dysfunction-associated fatty liver disease: Time to discard the emperor’s clothes of normal liver enzymes'. Together they form a unique fingerprint.

Cite this