Screening for linkage and association in nuclear families

M. Knapp, M. Durner, M. P. Baur

Research output: Contribution to journalArticlepeer-review


We applied linkage analysis with a sib‐pair method, which also takes into account information on unaffected siblings, and family‐based methods of association analysis to determine the disease affecting loci in Problem 1. Whereas the first two disease loci were correctly identified by association analysis, the sib‐pair linkage method failed to detect the disease loci 3 and 4. We therefore determined the data structure and sample size necessary for demonstrating linkage to these loci. ©1995 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)619-623
Number of pages5
JournalGenetic Epidemiology
Issue number6
StatePublished - 1995
Externally publishedYes


  • family‐based association analysis
  • sib‐pair method


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